| 白细胞介素-Ⅱ孵育自体淋巴细胞回输治疗慢性乙型肝炎及其机理初步探讨 |
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| 引用本文： | 陈成伟,李元斋,薛汉阳,杨广才,黄炳晨,汪更生,王月兰,姜石松,胡连芳,陶为荣,倪鎏达,傅青春.白细胞介素-Ⅱ孵育自体淋巴细胞回输治疗慢性乙型肝炎及其机理初步探讨[J].解放军医学杂志,1991(3). |
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| 作者姓名： | 陈成伟 李元斋 薛汉阳 杨广才 黄炳晨 汪更生 王月兰 姜石松 胡连芳 陶为荣 倪鎏达 傅青春 |
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| 作者单位： | 85医院
(陈成伟，李元斋，薛汉阳，杨广才，黄炳晨，汪更生，王月兰，姜石松，胡连芳，陶为荣，倪鎏达)，85医院(傅青春) |
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| 摘 要： | 用白细胞介素Ⅱ(IL-Ⅱ)孵育自体淋巴细胞回输治疗慢性乙型肝炎24例,并另以23例作对照。结果表明,治疗组与对照组HBeAg阴转率分别为54.2％和17.4％(P<0.05);HBeAg/抗-HBe转换率分别为37.5％和8.7％(P<0.05);治疗3个月谷丙转氨酶(ALT)复常率分别为83.3％和52.2％(P<0.05)。治疗组HBeAg/抗-HBe转换者均为慢性活动性肝炎,治疗中多伴有血清球蛋白升高;未出现HBeAg/抗-HBe转换者11例中有7例出现一过性ALT升高。
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| 关 键 词： | 白细胞介素-Ⅱ 自然杀伤细胞 淋巴因子活化杀伤细胞 慢性乙型肝炎 |
EVALUATION OF THE EFFECT OF INTERLEUKIN-2 ACTIVATED AUTOLOGOUS HUMAN PERIPHERAL BLOOD LYMPHOCYTES ON CHRONIC HEPATITIS B |
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| Chen Chengwei,Li Yuanzhai,Xue Hanyang,Yang Guangcai,Huang Bingchen,Wang Gengsheng,Wang Yuelan,Jiang Shisong,Hu Lianfang,Tao Weirong,Ni Liuda,Fu Qingchun.EVALUATION OF THE EFFECT OF INTERLEUKIN-2 ACTIVATED AUTOLOGOUS HUMAN PERIPHERAL BLOOD LYMPHOCYTES ON CHRONIC HEPATITIS B[J].Medical Journal of Chinese People's Liberation Army,1991(3). |
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| Authors: | Chen Chengwei Li Yuanzhai Xue Hanyang Yang Guangcai Huang Bingchen Wang Gengsheng Wang Yuelan Jiang Shisong Hu Lianfang Tao Weirong Ni Liuda Fu Qingchun |
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| Institution: | Chen Chengwei,Li Yuanzhai,Xue Hanyang,Yang Guangcai,Huang Bingchen,Wang Gengsheng,Wang Yuelan,Jiang Shisong,Hu Lianfang,Tao Weirong,Ni Liuda,Fu Qingchun. 85th Hospital,PLA |
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| Abstract: | 24 patients with chronic hepatitis B were treated with interleukin-2 activated human peripheral blood lymphocytes (IAPBL). 23 patients served as control. The results showed that HBeAg disappeared in 54.2% of IAPBL group, in comparison with 17.4% of the controls (P<0.05), and anti-HBe appeared in 37.5% of IAPBL group as compared with 8.7% of controls (P<0.05). 83.3% of IAPBL group and 52.2% of control group had the normal ALT level at the end of treatment (P<0.05). In IAPBL group, the disappearance of HBeAg and the presence of anti-HBe were accompanied by high serum globulin, while in the other patients who did not have marked change in HBV showed temporary elevation of ALT. |
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| Keywords: | Interleukin-2 Natural killer Autologous lymphokine activated killer cell Chronic hepatitis B |
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