Effect of statins use on the prevention of venous thromboembolism： a meta-analysis |
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| Authors: | Zhang Zaiwei Tian Hongyan Pan Junqiang Zhao Yaling Wan Zhaofei Zhang Junbo Ma Qiang Tian Hua Han Junli Liu Ya Deng Jizhao |
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| Institution: | 1. Department of Vascular Diseases, University Clinical Center Ljubljana, Zalo?ka cesta 7, 1000 Ljubljana, Slovenia;2. Diabetes & Me, Private Clinic for Diabetes, ?idovska 1, 1000 Ljubljana, Slovenia;1. Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, United States;2. Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, United States;3. Samuel Oschin Cancer Center, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States;4. Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, CA, United States |
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| Abstract: | ObjectiveTo estimate the effect of statins use on the prevention of venous thromboembolism (VTE).MethodsWe systematically searched MEDLINE (1980-June 2012), EMBASE (1980-June 2012), Google Scholar, Cochrane Library, and ISI Web of Science, manually reviewed references, and contacted experts. Case-control studies and cohort studies that compared any dose of statin with no statin or placebo are included. Data extraction and study quality evaluation were independently conducted in duplicate.Results12 studies including four cohort studies and eight case-control studies were identified and eligible for meta-analysis. Upon meta-analysis, statin use was associated with a statistically significant reduction in the odds of developing VTE (OR 0.91, 95% CI 0.86–0.96).ConclusionThis meta-analysis of current and available literature suggests that statins can reduce patient's risk of developing VTE. Due to the limitations of observational study, this conclusion should be considered with caution, and additionally, specifical well-designed trials are needed. |
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| Keywords: | Statins Venous thromboembolism Meta analysis |
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