相对低分子质量肝素对大鼠的抗凝血作用

目的：观察相对低分子质量肝素（LMWH）的抗凝作用。方法：大鼠予LMWH，sc后，采血进行体外循环试验且取血浆测定凝血指标。结果：2或4mg/kg的LMWH能显著延长纤维蛋白栓形成时间（TFT），显著减少血栓的干湿重量。1mg/kgLMWH仅能延长TFT和减少血栓长度。对常用凝血指标如全血凝血时间（CT）、复钙时间（RT）、凝血酶原时间（PT）和凝血酶时间（TT）也有显著的延长作用，但对白陶土部分凝血活酶时间（KPTT）作用较弱。普通肝素4mg/kg对以上各指标也有极显著的作用。结论：LMWH能抑制血栓形成，同时有导致出血的倾向。

Anti-coagulation effect of low molecular weight heparin

AIM: To evaluate the anti coagulation effect of low molecular weight heparin (LMWH). METHODS: After the rats were given LMWH, the blood was taken out for thrombosis test at the circulation ex vivo . Besides, the plasma was prepared for coagulation test. RESULTS: The results showed that 2 or 4 mg/kg LMWH significantly prolonged the beginning time of thrombus formation (TFT) and decreased the weight of wet and dry thrombus. But 1 mg/kg LMWH could only prolong the TFT and decrease the length of thrombus. The LMWH also significantly increased the values of CT, RT, TT and PT. The 4 mg/kg of normal heparin had the same effects too. CONCLUSION: LMWH has the effect to suppress the thrombus formation and tending to bleed.