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| 抑郁对大鼠前列腺增生影响的实验研究 | |
| 引用本文： | 黄小波,李宗信,李斌,郭德育,敖平,李曰庆. 抑郁对大鼠前列腺增生影响的实验研究[J]. 中国老年学杂志, 2003, 23(4): 245-246 |
| 作者姓名： | 黄小波 李宗信 李斌 郭德育 敖平 李曰庆 |
| 作者单位： | 1. 首都医科大学宣武医院,北京,100053 2. 中国中医研究院中药研究所 3. 北京中医药大学东直门医院 |
| 基金项目： | 北京市中医管理局资助项目 (NO990 2 2 ) |
| 摘 要： | 目的 探讨抑郁因素对大鼠前列腺增生的影响。方法 实验分为正常对照组、抑郁组、丙酸睾丸酮(TP)组及抑郁 TP组。抑郁组在大鼠颈部套一红色圆形项夹，TP组按每只1mg／d皮下注射。造摸3w后测定大鼠前列腺重量，计算前列腺指数，行HE染色观察形态学改变，组织增殖细胞核抗原(PCNA)免疫组化染色计算PCNA增殖指数。结果 单纯抑郁组前列腺指数及PCNA增殖指数显著高于对照组(P＜0．05)，组织学观察抑郁组前列腺有增生的表现。结论 抑郁对前列腺增生有一定的诱发作用。 |
| 关 键 词： | 抑郁 前列腺增生 实验 抑郁因素 形态学 丙酸睾丸酮 |
| 文章编号： | 1005-9202(2003)04-0245-02 |
| 修稿时间： | 2002-06-13 |
The influence of depression on benign prostatic hyperplasia in rats |
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| HUANG Xiao-bo,LI Zong-xin,LI Bin,et al. The influence of depression on benign prostatic hyperplasia in rats[J]. Chinese Journal of Gerontology, 2003, 23(4): 245-246 | |
| Authors: | HUANG Xiao-bo LI Zong-xin LI Bin et al |
| Abstract: | Objective To study the influence of depression on benign prostatic hyperplasia in rats Methods The rats were apportioned into normal control group, testosterone propionaste(TP) group, depression group and TP+ depression group The depression in rat was induced by a red loop, which were fixed around the cervix of rats ,1 mg TP was subcutaneously injected into rat every day At the end of third week, prostatic weight, prostatic index of rats were measured, and HE dyeing prostatic tissues section were observed PCNA multiplication index was calculated by immunohistochemistry method Results The prostatic index and PCNA multiplication index in depression group were significantly higher than control group(P<0 05) HE dyeing tissues section shows that prostatic hyperplasia happened in depression group Conclusions Depression could accelerate prostatic hyperplasia to a certain in rats |
| Keywords: | Depression Prostatic hyperplasia Rats |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |