肺放线菌病一例并文献复习

目的 提高对肺放线菌病发病机制、诊断、临床特点及治疗的认识.方法 报道2007年3月解放军总医院附属第一医院呼吸科收治的1例肺放线菌病病例并进行相关文献复习.结果 患者女,66岁.反复出现咳嗽、咳痰、低热4年,多次X线胸片均示右中叶肺炎,经支气管镜检查及病理诊断为肺放线菌病.经林可霉素联合磺胺甲嚼唑/甲氧苄啶治疗6个月后痊愈.结合本例并复习近20年国内外文献报道的187例肺放线菌病(国外162例,国内25例)资料,结果 显示本病男性多见,发病年龄为12～87岁;咳嗽、咳痰、胸痛为常见症状,咳黄色颗粒样物为典型表现,但并不多见.胸部CT可表现为实质团块影、片状影、实变影伴支气管充气征、空洞、纵隔淋巴结肿大、胸腔积液及胸膜增厚等.病变部位以左下叶及右中叶居多,与肺癌、肺结核易混淆.确诊主要依靠经支气管镜活检病理及手术病理检查,痰涂片及培养阳性率低.青霉素、四环素、红霉素、磺胺类或林可霉素等抗生素治疗及手术切除是主要的治疗手段.结论 肺放线菌病是一种少见病,早期诊断和治疗可获得良好疗效.

A case report of pulmonary actinomycosis and review of the literature

Objective To improve the awareness of primary pulmonary actinomycosis. Methods One case of primary endobronchial actinomycosis was reported and 187 cases of primary pulmonary actinomycosis reported in the literature were reviewed. Results A 66-year-old female had had recurrent cough, sputum production and fever for 4 years. Chest X-ray showed pneumonia in the right middle lobe. The diagnosis of pulmonary actinomycosis was confirmed by histopathological examination. The incidence of bronchopulmonary actinomycosis was 2 times higher in males than in females. The common clinical presentations included cough, sputum and chest pain with a shadow or shadows on chest radiograph. The findings on CT included patchy air-space consolidation, multifocal nodular appearance, cavitation, pleural effusions or thickening and hilar and/or mediastinal lymphadenopathy. Accurate diagnosis was generally made by histopathological examination of transbroncbosoopic biopsy or surgical samples. Penicillin, tetracycline ,erythromycin ,sulphanilanlide,lincomycin and surgical resection remained to be the treatment of choice over the last 50 years. Conclusion Primary bronchopulmonary actinomycosis is a rare infectious disease. Early diagnosis and proper treatment can lead to good outcomes with a low mortality.