VEGF和p53在胰腺癌中的表达及意义

目的　探讨胰腺癌组织中血管内皮生长因子 (VEGF)及p5 3蛋白的表达及其临床病理意义。方法　采用SP免疫组织化学方法 ,对 46例胰腺癌组织中VEGF及 p5 3蛋白的表达进行检测。结果　VEGF与 p5 3表达率分别为 65 .2 %和 5 8.7%。p5 3表达与VEGF表达呈明显正相关(P <0 .0 5 )。VEGF表达与胰腺癌淋巴结转移 (P <0 .0 5 )和远处转移 (P <0 .0 1)显著相关 ,而与肿瘤大小 ,病理学分级无关 ,p5 3表达与胰腺癌远处转移 (P <0 .0 5 )显著相关 ,而与肿瘤大小 ,病理学分级及淋巴结转移无关。结论　在胰腺癌中 ,VEGF表达与 p5 3蛋白的表达呈正相关 ,在胰腺癌的转移中起重要作用

Expression of VEGF and p53 in pancreatic cancer and its significance

Objective To investigate the expressions of vascular endothelial growth factor (VEGF) and p53 protein in pancreatic cancer and their clinicopathologic significance.Methods The expression of VEGF and p53 in 46 pancreatic cancer tissues was detected by SP immunohistochemistry.Results The expression rates of VEGF and p53 were 65.2% and 58.7% respectively.The positive correlation was noted between VEGF expression and p53 expression (P<0.05).The expression of VEGF was associated with lymph node metastasis(P<0.05) and distant metastasis(P<0.01),but not correlated with the size of tumor and pathological grade.The expression of p53 was associated with distant metastasis(P<0.05),but not correlated with the size of tumor,pathological grade and lymph node metastasis.Conclusion VEGF expression is associated significantly with the expression of p53,and plays an important role in metastases of pancreatic cancer.