Immunohistochemical localization of Na+,K+-ATPase in the human endolymphatic sac |
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| Authors: | P. A. Wackym M. E. Glasscock III F. H. Linthicum Jr. W. J. Ball Jr. U. Friberg H. Rask-Andersen |
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| Affiliation: | (1) Division of Head and Neck Surgery, UCLA School of Medicine, Los Angeles, California, USA;(2) House Ear Institute, 256 South Lake Street, 90057 Los Angeles, CA, USA;(3) Division of Neurotology, Vanderbilt University Medical Center, Nashville, Tennessee, USA;(4) Department of Pharmacology and Cell Biophysics, University of Cincinnati Medical Center, Cincinnati, Ohio, USA;(5) Department of Otolaryngology, University Hospital, Uppsala, Sweden |
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| Abstract: | Summary The presence and distribution of the transport protein complex Na+,K+-ATPase in the human endolymphatic sac (ES) was demonstrated immunohistochemically using a monoclonal antibody directed toward the denatured catalytic subunit of Na+,K+-ATPase from lamb kidney medulla. Our findings support an active transcellular ion exchange by the ES epithelium with subsequent passive transcellular and paracellular outflow of water. The possible role of the lateral intercellular spaces in the outflow of endolymph at the level of the ES is discussed. |
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| Keywords: | Na+, K+-ATPase Human endolymphatic sac Endolymph Meniere's disease |
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