| EDN1及EDNRA基因多态性与局部区域晚期鼻咽癌预后的关系 |
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| 引用本文： | 温月凤,齐斌,莫浩元,刘怀,陈秋燕,李娟,叶艳芳,郭翔,麦海强.EDN1及EDNRA基因多态性与局部区域晚期鼻咽癌预后的关系[J].中华肿瘤防治杂志,2010,17(18). |
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| 作者姓名： | 温月凤 齐斌 莫浩元 刘怀 陈秋燕 李娟 叶艳芳 郭翔 麦海强 |
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| 作者单位： | 华南肿瘤学国家重点实验室,中山大学肿瘤防治中心鼻咽科,广东,广州,510060 |
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| 基金项目： | 国家自然科学基金，"863计划"子课题，广东省科委项目，广东省医学科研基金，广州市科委项目 |
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| 摘 要： | 目的:探讨EDN1及EDNRA 基因多态性与初治局部区域晚期鼻咽癌患者预后的关系.方法:采用LDR-PCR技术对203例鼻咽癌患者EDN1及EDNRA基因7个位点的基因多态性(SNP)进行检测,用Kaplan-Meier法进行生存分析,多因素分析采用Cox回归模型.结果:携带EDNRA/H323H突变型杂合子TC基因型患者的5年无进展生存率(PFS)、总生存率(OS)、无远处转移生存率(DMFS)及无局部区域复发生存率均比携带纯合子CC+TT基因型的患者低,P<0.05; Cox模型多因素分析显示,EDNRA/H323H SNPs是影响局部晚期鼻咽癌患者PFS(HR:1.964;P=0.004)、OS(HR:1.955; P=0.009)、DMFS(HR:1.984;P=0.023)及LRFS(HR:2.112;P=0.036)的独立预后因素.携带EDNRA/G-231A突变基因型GA或AA患者的5年PFS和LRFS均低于携带野生型GG基因型患者(P<0.05),Cox模型多因素分析显示,EDNRA/G-231A SNPs是影响局部晚期鼻咽癌患者PFS(HR:1.826;P=0.017)及LRFS (HR:3.262;P=0.005)的独立预后因素.结论:EDNRA基因H323H、G-231A SNPs是影响局部区域晚期鼻咽癌的独立预后因素,为晚期鼻咽癌的预后判断及个体化治疗提供了新的分子指标.
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| 关 键 词： | 鼻咽肿瘤 内皮素-1 内皮素受体A 基因 综合疗法 预后 |
Prognostic role of endothelin-1 and endothelin A receptor gene polymorphisms in patients with locoregionally advanced nasopharyngeal carcinoma |
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| WEN Yue-feng,QI Bin,MO Hao-yuan,LIU Huai,CHEN Qiu-yan,LI Juan,YE Yan-fang,GUO Xiang,MAI Hai-qiang.Prognostic role of endothelin-1 and endothelin A receptor gene polymorphisms in patients with locoregionally advanced nasopharyngeal carcinoma[J].Chinese Journal of Cancer Prevention and Treatment,2010,17(18). |
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| Authors: | WEN Yue-feng QI Bin MO Hao-yuan LIU Huai CHEN Qiu-yan LI Juan YE Yan-fang GUO Xiang MAI Hai-qiang |
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| Institution: | WEN Yue-feng,QI Bin,MO Hao-yuan,LIU Huai,CHEN Qiu-yan,LI Juan,YE Yan-fang,GUO Xiang,MAI Hai-qiang State Key Laboratory of Oncology in South China,Department of Nasopharyngeal Carcinoma,Cancer Center,Sun Yat-sen University,Guangzhou 510060,P.R.China |
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| Abstract: | OBJECTIVE:To investigate the prognostic role of endothelin-1 and endothelin A receptor gene polymorphisms in patients with locoregionally advanced nasopharyngeal carcinoma (NPC).METHODS:The single nucleotide polymorphisms (SNPs) in 7 sites of the endothelin-1 and endothelin A receptor gene were detected from 203 NPC patients by LDR-PCR technique,and Kaplan-Meier method was used to analyze the survival rate,and multivariate analysis was performed with Cox regression model.RESULTS:The 5-year progression free ... |
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| Keywords: | nasopharyngeal neoplasms endothelin-1 endothelin A receptor gene combined modality therapy prognosis |
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