新生儿呼吸机相关性肺炎抗生素降阶梯疗法的疗效观察

目的评价新生儿呼吸机相关性肺炎（VAP）采用抗生素降阶梯疗法的疗效。方法分析了40例VAP患儿。治疗组17例用抗生素降阶梯疗法，与常规组比较疗效。结果一次撤机成功率治疗组大于常规组（P〈0.01），平均通气时间及通气〉1周者，治疗组（6.1天）短于、少于常规组（10．3天）（P〈0．01）。结论抗生素降阶梯疗法对VAP具有良好疗效。

The Effect of De - escalation Therapy of Antimicrobial Agents on the Treatment of Ventilator Assoeiated Pneumnonia

Objective To evaluate the effect of de-escalation therapy of antimicrobial agents on the treatment of ventilator assoeiated pneumnonia(VAP).Methods 40 VAP patients were evaluated.17 cases were treated by de-escalation therapy of antimicrobial agents,the rest were treated by routine therapy.Results The achievement ratio of machine removing was superiorer to that of routine therapy(P<0.01).Patients(average duration of ventilation>1 week) received de-escalation therapy of antimicrobial agents whose average duration of ventilation was shorter than that treated by routine therapy(P<0.01).Conclusions de-escalation therapy of antimicrobial agents has well curative effect on VAP.