宫内汞暴露与新生儿体格发育指数相关性研究

【目的】 研究宫内汞暴露对新生儿体格发育指数的影响。 【方法】 研究期间对本院分娩的新生儿生后即刻取脐带血,胎发进行汞含量测定。新生儿出生后分别测定体重、身长、头围。按娩出时胎龄对照我国15城市新生儿体格发育指数测量值,求出所在百分位区间,并将脐血汞、胎发汞值进行统计学分析。 【结果】 2 316例配对测定脐血汞为(2.02±1.94)μg/kg,胎发汞为(244.06±2.24)μg/kg。 按百分位区间(10,P₁₀~P₂₅,P₂₅~P₇₅,P₇₅~P₉₀,>P₉₀)头围各组脐血汞值依次分别为2.50±1.88,2.05±1.92,1.88±1.96,1.50±1.76,1.77±1.49;胎发汞分别为360.91±2.12,262.97±2.15,201.65±2.22,205.31±2.18,208.50±1.49,差异有统计学意义(F₁=15.47,P₁=0.00;F₂=42.53,P₂=0.00)体重各组胎发汞值依次分别为195.07±2.13,227.25±2.19,247.69±2.18,252.29±2.32,246.89±2.32,各组间差异有统计学意义(F=2.57,P<0.05),但去除10组后,其余4组差异无统计学意义(F=0.91、P=0.44)。 【结论】 宫内汞暴露除影响胎儿日后智力发育外,还可能对新生儿头围产生不利影响。

Relevance of intrauterine mercury exposure and neonatal physical development indices.

【Objective】 To research the impact of intrauterine mercury exposure on the neonatal physical development Index.【Methods】 During the study period,the new-born babies delivered in our hospital were determined with the quantity of mercury in cord blood and in foetal hair immediately after birth.The new-born babies weight,length and head circumference were measured.According to gestational age,physical development index measurements that the new-baorn babies in 15 cities of China for comparison,and the cord blood mercury and fetal hair mercury values were analyzed in the percentile range for statistical analysis.【Results】 The quantity of mercury of 2 316 paired cases was(2.02±1.94)μg/kg in cord blood,and(244.06±2.24)μg/kg in foetal hair.Cord blood mercury of head circumference in each group which was divided by percentile range(P90) was 2.50±1.88,2.05±1.92,1.88±1.96,1.50±1.76,1.77±1.49 respectively,and fetal hair mercury in each group was 360.91±2.12,262.97±2.15,201.65±2.22,205.31±2.18,208.50±1.49 respectively.There were significant differences among cord blood mercury groups and fetal hair mercury groups(F1=15.47,P1=0.00;F2=42.53,P2=0.00).Cord blood mercury of weight in each group was 195.07±2.13,227.25±2.19,247.69±2.18,252.29±2.32,246.89±2.32 respectively,and there was significant difference among cord blood mercury groups(F=2.57,P<0.05).However,after removal of