Telephone Validation of the Quality of Life in Epilepsy Inventory-89 (QOLIE-89) |
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Authors: | Nancy Kline Leidy Anne Elixhauser Anne M. Rentz Robert Beach John Pellock Steven Schachter Mary Kay Willian |
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Affiliation: | Center for Health Outcomes Research, MEDTAP International, Inc., Bethesda, Maryland;Department of Neurology at the University of North Carolina Hospitals in Chapel Hill, North Carolina;Comprehensive Epilepsy Institute at the Medical College of Virginia of Virginia Commonwealth University in Richmond, Virginia;Comprehensive Epilepsy Center at Beth Israel Deaconess Medical Center in Boston, Massachusetts;Astra Merck, Inc. |
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Abstract: | Summary: Purpose: To assess the psychometric properties of the Quality of Life in Epilepsy Inventory-89 (QOLIE-89) administered via telephone and to compare these properties with data gathered through self-administration. Methods: A study of 139 patients with epilepsy was undertaken at three clinical sites in the United States. Patients participated in both telephone interview (T) and self-administration (S). Order effect was controlled through randomization (T-S and S-T). Twenty-eight S-T subjects participated in an assessment of the 2-week reproducibility of telephone interviews. Results: Internal consistency and test-retest reliability levels of the QOLIE-89 overall score were very high across method of administration (T = 0.98; S = 0.98; ICC of T = 0.96). Scores were significantly related to mood (Profile of Mood States, r = -0.76, for both methods, p > 0.001) and two indicators of epilepsy severity (seizure frequency in the past month, T: r = 0.52, p > 0.0001; S: r = 0.54, p > 0.0001; days since last seizure, T: r = 0.28, p > 0.001; S: r = 0.25, p > 0.01), with no significant differences in coefficients by method of administration. Performance of the measure was consistent for patients with unimpaired and impaired memory, using the River-mead Behavioural Memory Test, and across level of education. Conclusions: Results of this study indicate telephone interview is a viable option for evaluating HRQL in persons with epilepsy and support the reliability and validity of the QOLIE-89 regardless of method of administration. |
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Keywords: | Epilepsy Outcomes Quality of life Methodology |
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