Vaccine efficacy of a lysine auxotroph of Mycobacterium tuberculosis |
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| Authors: | Pavelka Martin S Chen Bing Kelley Cynthia L Collins Frank M Jacobs Jr William R |
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| Institution: | Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA. |
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| Abstract: | The in vivo growth phenotype and vaccine efficacy of a lysine auxotrophic mutant of Mycobacterium tuberculosis strain H37Rv are described. An immunization experiment using a mouse model with an aerosol challenge showed that two doses of the M. tuberculosis mutant were required to generate protection equivalent to that of the Mycobacterium bovis BCG vaccine. |
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