| 小泛素样修饰蛋白-1对α-突触核蛋白基因突变或过表达诱导的细胞包涵体形成及细胞凋亡的影响 |
| |
| 作者姓名： | Chen T Liao XP Wen GQ Long ZG Ouyang F Deng YD Guo M |
| |
| 摘 要： | 目的 探讨α-突触核蛋白(α-synuclein)的小泛素样修饰蛋白(small ubiquitin-like modifier,SUMO)-1对α-synuclein基因过表达或突变诱导的细胞包涵体形成及细胞凋亡的影响.方法 构建野生型(WT)、A53T突变型和缺失SUMO-1互作氨基酸的K96R突变型、K96R-A...
|
| 关 键 词： | α-突触核蛋白基因 小泛素修饰蛋白-1 细胞包涵体 细胞凋亡 帕金森病 |
The effect of small ubiquitin-like modifier-1 modification on the formation of Lewy body-like inclusions in cytoplasm and apoptosis of HEK293 cell induced by overexpression and mutation of alpha-synuclein |
| |
| Chen T,Liao XP,Wen GQ,Long ZG,Ouyang F,Deng YD,Guo M.The effect of small ubiquitin-like modifier-1 modification on the formation of Lewy body-like inclusions in cytoplasm and apoptosis of HEK293 cell induced by overexpression and mutation of alpha-synuclein[J].Chinese Journal of Medical Genetics,2011,28(5):511-516. |
| |
| Authors: | Chen Tao Liao Xiao-ping Wen Guo-qiang Long Zhi-gang Ouyang Feng Deng Yi-dong Guo Min |
| |
| Institution: | Department of Neurology, Hainan Provincial People's Hospital, Haikou, Hainan, People's Republic of China. ctxwyc@163.com |
| |
| Abstract: | |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
