Design, synthesis and antifungal activity of some new imidazole and triazole derivatives |
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Authors: | Rezaei Zahra Khabnadideh Soghra Zomorodian Kamiar Pakshir Kyvan Kashi Giti Sanagoei Narges Gholami Sanaz |
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Institution: | Department of Medicinal Chemistry, Shiraz University of Medical Sciences, Iran. rezaeiza@sums.ac.ir |
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Abstract: | Triazole and imidazole are incorporated into the structures of many antifungal compounds. In this study a novel series of 1,2,4-triazole, imidazole, benzoimidazole, and benzotriazole derivatives was designed as inhibitors of cytochrome P450 14α-demethylase (14DM). These structures were docked into the active site of MT-CYP51, using Autodock program. Sixteen compounds with the best binding energy were synthesized. The chemical structures of the new compounds were confirmed by elemental and spectral ((1) H-NMR and Mass) analyses. All compounds were investigated for antifungal activity against Candida albicans, Candida tropicalis, Candida glabrata, Candida parapeilosis, Candida kruzei, Candida dubliniensis, Aspergillus fomigatus, Aspergillus flavus, Microsporum canis, Microsporum gypseum, Trichophyton mentagrophyte, Epidermophyton floccosum. Some compounds showed excellent in-vitro antifungal activity against most of the tested fungi. Compounds 2, 9, and 10 had antifungal activity against several resistant fungi against fluconazole and itraconazole. |
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Keywords: | Antifungal activity Docking Imidazole Triazole |
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