烧伤早期切痂对大鼠心肺血管通透性影响

目的：探讨烧伤早期切痂对脏器血管通透性的影响，阐明烧伤早期切痂对脏器功能损害的防治作用。方法：Wistar大鼠随机分为烧伤组（A），早期切痂组（B）及正常对照组，采用^99锝标记白蛋白测定心、肺血管通透性变化，同时，对比早期切痂组血清对体外培养内皮细胞单层通透影响。结果：大鼠严重烧伤后心、肺血管通透性增加，B组血管通透性较A组降低；B组烧伤血清较A组烧伤血清可降低体外培养内皮细胞单层通透性的增加。结论：烧伤早期切痂植皮有利于降低烧伤后脏器血管通透性的增加。

Effects of early postburn escharectomy on the permeability of cadiac and pulmonary blood vessels in rats

Objective To evaluate the prophylactic-therapeutic role of escharectomy during early postburn stage on internal organ dysfunction. Methods A total of 72 Wistar rats were randomized into 3 groups: burn without escharectomy group (A group), burn with escharectomy during early postburn stage (B group) and normal control. Vascular permeability were measured with 99Tc-labelled albumin. Furthermore, the effect of burn sera on permeability of monolayer of vascular endothelial cell (EC) was observed. Results Vascular permeability in group B was significantly lower than in group A. When exposed to burn sera, EC monolayer permeability in group B is decreased when compared with group A. Conclusion Escharectomy during early postburn stage could restore endothelial permeability