应用超声检查评价甲状腺功能亢进患者血管僵硬度与心功能的关系

目的:应用超声检查评价甲状腺功能亢进(以下简称甲亢)患者动脉僵硬度和心功能的关系。方法:分别检测、计算甲亢组(67例)与对照组(45例)的心功能和颈动脉血管僵硬度参数,并进行两组间比较。结果:甲亢组二尖瓣口舒张早期血流速度峰值(E峰)与左心室后壁二尖瓣环舒张早期速度峰值(e峰)比值(E/e)及Tei指数高于对照组,两组比较差异有统计学意义(P<0.05);射血分数两组间比较差异无统计学意义(P>0.05)。甲亢组血管僵硬度参数(β)、脉搏波传导速度(PWV)高于对照组,两组差异有统计学意义(P<0.05)。E/e,Tei指数与PWV呈正相关,射血分数与血管僵硬度参数无相关性。结论:甲亢引起动脉僵硬度增高,心功能障碍;动脉硬化可作为早期心功能障碍预测指标之一。

Preliminary research of relationship between vascular stiffness and heart function in patients with hyperthyroidism

Objective:To assess the relationship between arterial stiffness and heart function in patients with hyperthyroidism using ultrasonography.Methods:A total of 67 patients with hyperthyroidism and 45 controls were enrolled,and the parameters of arterial stiffness and heart function were measured and calculated.The results were analyzed and compared.Results:The ratio of peak early-diastolic mitral orifice flow velocity and peak early-diastolic mitral annular velocity in left ventricular posterior wall(E/e),and Tei index were significantly higher in hypertension group than in controls,but there was no significant difference in ejection fraction(EF) between the two groups.In hyperthyroidism group,the parameters of arterial stiffness including β and Pulse wave velocity(PWV) were higher than in controls,There were significant differences betweenthe two groups(P<0.05).The E/e and Tei index were positively correlated with PWV(P<0.05).There was no significant correlation between EF and arterial stiffness.Conclusion:The arteriaI stiffness and damage of heart function can result from hyperthyroidism.The arterial stiffness can be one of monitoring indexes for the heart function damage in earlytime.