| 蛋白质氧化与阿尔茨海默病 |
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| 引用本文： | 任惠民. 蛋白质氧化与阿尔茨海默病[J]. 中国临床神经科学, 2010, 18(4): 410-418,430 |
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| 作者姓名： | 任惠民 |
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| 作者单位： | 复旦大学附属华山医院中心实验室,神经科,200040 |
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| 摘 要： | 阿尔茨海默病（AD）是与老年相关的进展性神经变性疾病,主要分子病理学特征为脑内淀粉样蛋白（Aβ）沉积形成的老年斑和过度磷酸化tau蛋白所形成的神经纤维缠结.氧化应激是包括AD在内的神经变性病的一个重要发病机制.本文介绍了氧化应激后蛋白质发生改变的类型、AD进展期间脑内蛋白质的氧化、Aβ沉积和tau蛋白过度磷酸化的原因以及今后对AD进行预防与治疗的一些策略.
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| 关 键 词： | 阿尔茨海默病 蛋白质氧化 Aβ蛋白沉积 过度磷酸化tau蛋白 预防与治疗 |
Protein Oxidation and Alzheimer's Disease |
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| REN Hui-Min. Protein Oxidation and Alzheimer's Disease[J]. Chinese Journal of Clinical Neurosciences, 2010, 18(4): 410-418,430 |
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| Authors: | REN Hui-Min |
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| Affiliation: | REN Hui-Min (The Center Laboratory of Huashan Hospital, Department of Neurology, Fudan University, Shanghai 200040, China) |
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| Abstract: | Alzheimer＇ s disease （AD） is a progressive neurodegenerative disorder associated with aging, and molecular pathological characterized by the deposition of β-amyloid （Aβ） into plaques and neurofibrillary tangles （NFTs） composed of hyperphosphorylated tan protein. The oxidative stress is an important mechanism of neurodegenerative disorders including AD. In this review, the types of proteins modified by oxidative stress, protein oxidation in brain during AD progression, the causes of amyloid deposition and tau hyperphosphorylation, and several strategies for preventing and treating AD in future were introduced resumptively. |
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| Keywords: | Alzheimer＇ s disease protein oxidation amyloid deposition tau hyperphosphorylation prevention and treatment |
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