| 急性缺血性卒中时间窗外溶栓治疗的现状 |
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| 引用本文： | 徐雅婧 余丹. 急性缺血性卒中时间窗外溶栓治疗的现状[J]. 中华临床医师杂志(电子版), 2014, 0(10): 1915-1919 |
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| 作者姓名： | 徐雅婧 余丹 |
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| 作者单位： | 中南大学湘雅医学院附属海口医院神经内科,570208 |
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| 摘 要： | 静脉注射阿替普酶(重组组织型纤溶酶原激活剂,tPA)是脑梗死早期公认的治疗方法。但由于严格的溶栓时间窗、获得溶栓同意及出血风险等限制,多数符合溶栓条件的患者并没有得到溶栓治疗(溶栓治疗率仅达3%),寻找更有效、安全、时间窗外的溶栓治疗显得尤为重要。本文就溶栓药物新出路、影像指导溶栓、超声辅助溶栓以及血管内机械取栓等方面进行了探讨。
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| 关 键 词： | 脑梗死 卒中 组织型纤溶酶原激活物 溶栓治疗 超时间窗 |
Progress in extending thrombolytic time window in the therapy of acute ischemic stroke |
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| Xu Yajing,Yu Dan. Progress in extending thrombolytic time window in the therapy of acute ischemic stroke[J]. Chinese Journal of Clinicians(Electronic Version), 2014, 0(10): 1915-1919 |
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| Authors: | Xu Yajing Yu Dan |
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| Affiliation: | (Department of Neurology, Affiliated Haikou Hospital of Xiangya Medical College of Central South University, Haikou 570208, China) |
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| Abstract: | Currently, the only approved treatment for acute ischemic stroke （AIS） is intravenous （IV） alteplase [recombinant tissue plasminogen activator （tPA）], administered during the first 3 hours following the onset of symptoms. However, less than 3% of patients with an ischemic stroke receive IV alteplase. Therefore, new therapeutic strategies are aimed at improving effectiveness of thrombolysis and extending the 4.5 h therapeutic time window. Thrombolysis beyond the therapeutic time window, will be the focus of future treatment, and affect the outcome of patients with acute cerebral infarction. |
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| Keywords: | Brain infarction Stroke Tissue plasminogen activator Thrombolysis Therapeutic time window |
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