上皮钙黏蛋白及其复合体的表达与垂体腺瘤侵袭性的相关性

目的探讨上皮型钙黏蛋白（E-cadherin,E-cad）及其与连环蛋白复合体（cadherincatenin complex,CCC）的表达与垂体腺瘤侵袭性的关系.方法垂体腺瘤78例,按Cottier等提出的鞍区MRI影像学判定标准将其分为侵袭性垂体腺瘤和非侵袭性垂体腺瘤.其中侵袭性垂体腺瘤44例,非侵袭性垂体腺瘤34例.免疫组织化学SP法检测E-cad及其复合体在侵袭性垂体腺瘤和非侵袭性垂体腺瘤中的表达.分析E-cad及其复合体的表达与垂体腺瘤激素分泌、是否伴有瘤卒中、坏死、囊性变及肿瘤大小等生物学行为的关系.结果44例侵袭性垂体腺瘤中30例（68.2%）表现为E-cad、α-cat和β-cat一致性低表达,14例（31.8%）表现为E-cad、α-cat和β-cat高、低表达特征无一致性.E-cad、α-cat在侵袭性垂体腺瘤和非侵袭性垂体腺瘤之间的表达差异有统计学意义（χ^2=13.969,P＜0.01）;β-cat在侵袭性垂体腺瘤的表达较非侵袭性垂体腺瘤表达低,但差异无统计学意义（χ^2=0.430,P＞0.05）;E-cad、α-cat在大腺瘤组较微腺瘤组表达低,两组之间差异有统计学意义（χ^2=5.038,P＜0.05）.E-cad在无功能垂体腺瘤较激素分泌性垂体腺瘤表达低,两组之间差异有统计学意义（χ^2=4.614,P＜0.05）.β-cat在伴有瘤卒中、坏死、囊性变组较不伴有组表达低,两组之间差异有统计学意义（χ^2=6.701,P＜0.05）.结论E-cad及其复合体的低表达或表达缺失与垂体腺瘤的侵袭性有关.

Expression of E-cadherin catenin complex and invasiveness of pituitary adenoma

OBJECTIVE: To explore the relationship between the E-cadherin catenin complex and invasiveness of pituitary adenoma. METHODS: The expression of E-cadherin catenin complex was determined by immunohistochemistry in 78 cases of human pituitary adenomas including invasive adenoma 44 cases, noninvasive adenoma 34 cases and the relativity of their expressions with hormone-producing, pituitary apoplexy and necrosis or cystoid change, tumor diameter were analyzed. RESULTS: The invasive group had a significantly lower expression of E-cad and alpha-cat than that of noninvasive group (chi-squared = 13.969, P < 0.01). There was no statistical significance for beta-cat expression between the invasive group and noninvasive group (chi-squared = 0.430, P > 0.05). Moreover, the expressions of beta-cad and alpha-cat were significantly lower in macro-adenoma group than that in micro-adenoma group (chi-squared = 5.038, P < 0.05). The expression of E-cad was significantly lower in endocrine inactive group than that in endocrine active group (chi-squared = 4.614, P < 0.05). The expression of beta-cat was significantly lower in the group with apoplexy and necrosis than that in the group without apoplexy and necrosis (chi-squared = 6.701, P < 0.05). CONCLUSIONS: The reduction of E-cad catenin complex is related to invasiveness and clinical pathological characteristics.