《普济方》治疗积聚类高频药物抑瘤作用的最佳配伍比例研究 |
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引用本文: | 邱泽玲,汤宇,唐前,张松兴.《普济方》治疗积聚类高频药物抑瘤作用的最佳配伍比例研究[J].实用中医内科杂志,2010,24(6):31-33. |
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作者姓名: | 邱泽玲 汤宇 唐前 张松兴 |
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作者单位: | 1. 辽宁省沈阳市皇姑区第一人民医院,辽宁沈阳,110032 2. 辽宁中医药大学附属医院,辽宁沈阳,110032 3. 辽宁中医药大学附属第二医院,辽宁沈阳,110034 |
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摘 要: | 目的]检索《普济方》中治疗积聚类痰病所用频次最高的中药大黄、当归、木香的不同配伍对艾氏腹水癌荷瘤小鼠抑瘤作用及免疫功能的影响,探讨大黄当归木香的最佳配伍关系。方法]制备艾氏腹水癌荷瘤小鼠动物模型,随机分为模型组、大黄组、大黄当归组、大黄木香组、大黄当归木香组;通过测定荷瘤小鼠的瘤重、脾重,计算抑瘤率及脾指数,观察不同配伍组对肿瘤生长及对免疫功能的影响。结果]大黄当归组对艾氏腹水癌的抑瘤率达到73.42%,脾指数2.431±0.48,与模型组比较,均具有统计学意义(P<0.05)。结论]结合抑瘤率与脾指数,大黄当归组合在本次实验中作用最好。
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关 键 词: | 艾氏腹水癌 大黄 当归 木香 配伍比例 抑瘤作用 |
"Puji Party" Type High Frequency of Drug Treatment of the Accumulation of Inhibitory Effect of the Ratio of the Best Compatibility |
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Authors: | QIU Ze-ling TANG Yu TANG Qian ZHANG Song-xing |
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Institution: | QIU Ze -ling, TANG Yu ,TANG Qian, ZHANG Song -xing( 1. Shenyang Huanggu District First People's Hospital, Shenyang 110032, Liaoning, China ; 2. The Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032 ,Liaoning,China ; 3. The Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 110034, Liaoning, China) |
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Abstract: | Objective]To observe, "Puji party" in the treatment of diseases used to accumulate the highest frequency of rhubarb, angelica, costas of different combinations of the Ehrlich ascites carcinoma tumor - bearing mice with anti -tumor effect and immune function, and to explore rhubarb the best compatibility between Angelica costas. Methods ] The preparation of Ehrlich ascites carcinoma animal models of tumor - bearing mice were randomly divided into model group, rhubarb group, rhubarb angelica group, rhubarb wood group, rhubarb angelica eostas group; by measuring the tumor -bearing mice, tumor weight, spleen weight calculate the inhibition rate and the spleen index, the effects of different compatibility groups of tumor growth and immune function. Results ] rhubarb angelica group Ehrlich ascites carcinoma tumor inhibition rate reached 73.42% , spleen index of 2. 431 ± 0.48, compared with model group, were statistically significant (P 〈 0. 05). Conclusion] The combination of inhibition rate and the spleen index, rhubarb angelica combined role in this experiment is best. |
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Keywords: | Ehrlich aseites carcinoma rhubarb angelica woody compatibility ratio antitumor effect |
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