| Nimodipine对冷冻伤性脑水肿的脑保护作用 |
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| 引用本文： | 陈立华,曹美鸿.Nimodipine对冷冻伤性脑水肿的脑保护作用[J].中国临床神经科学,1997,5(1):6-9. |
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| 作者姓名： | 陈立华 曹美鸿 |
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| 作者单位： | 湖南医科大学湘雅医院神经外科 410008
(陈立华，曹美鸿，秦天森，袁贤瑞，马建荣，李东升，张明宇)，湖南医科大学湘雅医院神经外科 410008(彭泽峰) |
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| 摘 要： | 本文观察了冷冻伤性脑水肿不同时间大鼠脑含水量和伊文思蓝(EB)含量的变化,脑含水量与EB含量之间的关系;以及尼莫地平(Nimodipine,Nim)对冷冻伤性脑水肿脑含水量和EB含量的影响。结果表明:冷冻伤脑含水量和EB含量明显升高,应用Nim治疗后,脑组织水分含量和EB含量明显降低,脑水肿减轻。这为临床颅脑损伤应用Nim治疗提供理论依据。
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| 关 键 词： | 冷冻伤 脑水肿 Nimodipine |
Protective Effect of Nimodipine on Brain Tissues in Rats Brain Edema with Freezing Injury |
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| Chen Li-Hua Cao Mei-Houng,Qin Tian-Sen,et al.Protective Effect of Nimodipine on Brain Tissues in Rats Brain Edema with Freezing Injury[J].Chinese Journal of Clinical Neurosciences,1997,5(1):6-9. |
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| Authors: | Chen Li-Hua Cao Mei-Houng Qin Tian-Sen |
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| Institution: | Chen Li-Hua Cao Mei-Houng,Qin Tian-Sen,et al
Department of neurosurgery,Xiang Ya Hospital,Hunan Medical
University,Hunan Changsha 410008 |
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| Abstract: | The changes of brain water content and Evans blue in following brain injury in 47 SD rats were studied. The water content and Evans blue content of brain tissues in rats brain edema with Freezing injury (FI) was observed. Nimodipine (Nim) was employed to show its effect on the brain edema induced by FI. The results showed that the brain water content and EB content increased significantly at 4 hours, 24 hours after brain injury (P<0. 05). There was a close relationship between water content and EB content. The results also showed that Nimodipine could significantly reduce brain water and EB content, brain edema was attenuated. Nimodipine had the advantage in treatment of FI brain edema. |
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| Keywords: | freezing injury brain edema Nimodipine |
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