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| 复方刺山柑胶囊的质量标准研究 | |
| 引用本文： | 袁涛,杨伟俊,罗玉琴,薛文采,程波.复方刺山柑胶囊的质量标准研究[J].中国医药导报,2013,10(25):100-103. |
| 作者姓名： | 袁涛 杨伟俊 罗玉琴 薛文采 程波 |
| 作者单位： | 1. 新疆维吾尔自治区克拉玛依市中心医院,新疆克拉玛依,834000 2. 新疆维吾尔自治区药物研究所新疆维吾尔药重点实验室,新疆乌鲁木齐,830004 3. 中国科学院新疆理化技术研究所中国科学院干旱区植物资源化学重点实验室,新疆乌鲁木齐,830011 |
| 基金项目： | 新疆维吾尔自治区科技计划项目 |
| 摘 要： | 目的 建立复方刺山柑胶囊的质量控制标准.方法 采用TLC法对制剂中川西獐牙菜、大黄、黄芪、木香、诃子进行定性鉴别;采用HPLC法对制剂中大黄素、大黄酚进行定量测定.结果 薄层色谱主斑点清晰、特征明显、专属性强;大黄素线性范围为0.768～3.840 μg/mL（r=0.9996,n=5）,平均回收率为100.00％ （RSD=1.18％）;大黄酚线性范围为2.04～16.32 μg/mL（r=0.9993,n=5）,平均回收率为l00.62％（RSD=0.38％）.结论 检测方法简便、可靠、重复性好,可作为复方刺山柑胶囊的质量标准控制方法. |
| 关 键 词： | 复方刺山柑胶囊 川西獐牙菜 大黄 薄层色谱 含量测定 |
Study on the quality standard of Compound Cishan'gan Capsules |
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| YUAN Tao , YANG Weijun , LUO Yuqin , XUE Wencai , CHENG Bo.Study on the quality standard of Compound Cishan'gan Capsules[J].China Medical Herald,2013,10(25):100-103. | |
| Authors: | YUAN Tao YANG Weijun LUO Yuqin XUE Wencai CHENG Bo |
| Institution: | 1. Karamay Center Hospital, Xinjiang Uygur Autonomous Region, Karamay 834000, China; 2.Xinjiang Institute of Materia Medica Key Laboratory of Xinjiang Uighur Medicine, Xinjiang Uygur Autonomous Region, Urumqi 830004, China; 3.Xinjiang Technical Institute of Physics and Chemistry of Chinese Academy of Sciences The Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Uygur Autonomous Region, Ummqi 830011, China) |
| Abstract: | Objective To establish the quality control standard of Compound Cishan＇gan Capsules.Methods Swertiae Mussoth Herba,Rhei Radix et Rhizoma,Astragali Radix,Aucklae Radix,Chebulae Fructus were identified by TLC.The HPLC in preparations for emodin and chrysophanol were quantificationally analyzed.Results The characteristic for identification by TLC was distinct and highly specific.The linear range of emodin was 0.768-3.840 μg/mL （r =0.9996,n=5）,and the average recovery was 100.00％ （RSD =1.18％）; the linear range of chrysophanol was 2.04-16.32 μg/mL （r =0.9993,n =5）,and the average recovery was 100.62％ （RSD =0.38％）.Conclusion The detection method is simple,reliable,reproducible,and can be suitable for quality control of Compound Cishangan Capsules. |
| Keywords: | Compound Cishan'gan Capsules Swertiae Mussoth Herba Rhei Radix et Rhizoma TLC Content determination |
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