西格列汀联合胰岛素治疗2型糖尿病短期效果观察

目的 探讨西格列汀联合胰岛素治疗使用胰岛素血糖控制不佳的2型糖尿病患者的临床效果.方法 将40例使用胰岛素血糖控制不佳的患者随机分为西格列汀组和对照组,各20例.西格列汀组在原治疗方案上加用西格列汀100 mg,每日1次,口服,并根据血糖情况调整胰岛素用量,对照组继续原治疗方案,根据血糖情况调整胰岛素用量,观察3周后空腹血糖、餐后血糖、胰岛素用量的改变.结果 3周后空腹血糖方面,西格列汀组减少（3.27±0.28）mmol/L,相比于对照组减少（2.46±0.41）mmol/L,下降更加明显,差异有统计学意义（P＜0.05）；餐后血糖方面,西格列汀组减少（4.58±0.34）mmol/L,相比于对照组减少（3.63±0.39） mmol/L,下降更加明显,差异有统计学意义（P＜0.05）.西格列汀组胰岛素用量减少了（3.40±0.77） U/d,对照组胰岛素用量增加了（4.05±0.39）U/d,差异有统计学意义（P＜0.05）.安全性方面,联用西格列汀组低血糖的比例（2例,10％）与对照组发生低血糖的比例（3例,15％）相比,差异无统计学意义（P＞0.05）.结论 西格列汀联用胰岛素的治疗方案治疗使用胰岛素血糖控制不佳的2型糖尿病患者,可以很好地控制血糖,治疗有效.

A short-term observation on treatment of type 2 diabetes with Sitagliptin and insulin

Objective To explore the effect of combination of Sitagliptin and insulin in treatment of type 2 diabetes. Methods 40 type 2 diabetes patients with not well controlled hyperglycemia were divided randomly into two groups, experimental group and control group, with 20 cases in each group. The patients in experimental group were given Sitagliptin 100 mg once a day in addition to the original treatment plan, while the patients in the control group contin- uing their medications. All the patients adjust their insulin doses according to the glucose level. 3 weeks later, fasting blood glucose （FBG）, postprandial blood glucose （PBG）, insulin dose were tested to see if there was any change. Results After 3 weeks, on the side of FBG, experimental group was decreased by （3.27±0.28） mmol/L, while the control group was decreased by （2.46±0.41） mmol/L, the difference was statistically significant （P 〈 0.05）. On the side of PBG, experi- mental group was decreased by （4.58±0.34） mmol/L, while the control group was decreased by （3.63±0.39） mmol/L, the difference was statistically significant （P 〈 0.05）. The insulin dose was reduced by （3.40±0.77） U/d, while it was increased by （4.05±0.39） U/d in control group, the difference was statistically significant （P 〈 0.05）. There was no significant dif ference between experimental group （2 cases, 10%） and control group （3 cases, 15%） in the proportion of hypoglycemia. Conclusion Combination of Sitagliptin and insulin can decrease blood glucose level significantly. It is effective.