中草药来源的醛糖还原酶抑制剂的研究进展

中草药作为天然产物,无明显不良反应且来源广泛,以中草药为来源的醛糖还原酶抑制剂其不良反应远低于化学合成及微生物来源的醛糖还原酶抑制剂,在有效阻止和延缓糖尿病并发症如:糖尿病肾病、血管病变、视网膜病变、外周神经病变方面显示了良好的应用前景。作者主要综述了中草药活性成分黄酮类化合物及其衍生物,如:槲皮素、水飞蓟素、葛根素、黄芩苷、黄连素等和一些中药复方制剂,如:参丹健胰丸、筋脉通、六味地黄丸等在抑制醛糖还原酶的活性、降低山梨醇含量等方面取得的研究进展,并对其在治疗糖尿病并发症方面的现状进行了阐述。

Progress in research of aldose reductase inhibitors in traditional medicinal herbs

The traditional medicinal herbs are natural product,and have no obviously toxic action and side effect,and their resources are extensive.The adverse effects produced by aldose reductase inhibitors in tradi-tional medicinal herbs are less than those from chemical synthesis and micro-organism,they can effectively pre-vent and delay diabetic complication,such as diabetic nephropathy,vasculopathy,retinopathy,peripheral neuro-pathy,and so on.They will have a wonderful respect.Flavonoid compounds and their derivates from tradition-al medicinal herbs are active inhibitors to aldose reductase,such as quercetin,silymarin,puerarin,baicalim,berberine and so on.In addition,some compound preparations show more strongly activity in inhibiting aldose reductase and degrading sorbitol contents,such as Shendan Jianyi capsule,Jinmaitong composita,Liuwei Di-huang pill,et al.The progresses in traditional medicinal herbs being active inhibitors and definite functions of treating diabetes complications have been reviewed.