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GABA-immunoreactive neurons in the dorsal lateral geniculate nucleus of the rat: characterisation by combined Golgi-impregnation and immunocytochemistry |
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| Authors: | P. L. A. Gabbott J. Somogyi M. G. Stewart J. Hámori |
| Affiliation: | (1) 1st Department of Anatomy, Semmelweis University Medical School, Tüzolto u. 58, H-1450 Budapest, Hungary;(2) Brain Research Group, Department of Biology, The Open University, Walton Hall, MK7 6AA Milton Keynes, UK;(3) Department of Experimental Psychology, University of Oxford, South Parks Road, OX1 3UD Oxford, UK |
| Abstract: | Summary Identified neurons in the dorsal lateral geniculate nucleus (dLGN) of the rat were studied using a Golgi/EM procedure in combination with post-embedding GABA immunocytochemistry. The results of this investigation identify clearly the GABA-immunoreactive nature of the two morphologically] distinct neuronal populations found within the rat dLGN — thalamocortical relay cells are GABA-immunonegative whilst the putative  interneurons are GABA-immunopositive. This immunocytochemical evidence strongly suggests that interneurons synthesize and use GABA to mediate their local inhibitory synaptic mechanisms within the dLGN of the rat. |
| Keywords: | Rat Dorsal lateral geniculate nucleus (dLGN) Interneurons Golgi/EM GABA immunocytochemistry |
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