| 中国北方汉族人群HLA-Cw~*高分辨等位基因频率分析 |
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| 引用本文： | 梁晓岚,韩俊领,李茜,孙乐静,杜颖,刘兰婷,邱录贵.中国北方汉族人群HLA-Cw~*高分辨等位基因频率分析[J].中国实验血液学杂志,2010,18(2):486-489. |
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| 作者姓名： | 梁晓岚 韩俊领 李茜 孙乐静 杜颖 刘兰婷 邱录贵 |
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| 作者单位： | 1. 协和干细胞基因工程有限公司,天津市脐带血造血干细胞库,天津,300384;中国医学科学院、北京协和医学院血液学研究所、血液病医院,天津,300020
2. 协和干细胞基因工程有限公司,天津市脐带血造血干细胞库,天津,300384 |
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| 基金项目： | 天津市科技创新专项资金,编号08FDZDSH03000 |
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| 摘 要： | 本研究从基因水平了解HLA-Cw*位点在中国北方汉族人群中的分布频率,分析HLA-Cw*等位基因的群体遗传学特点及基因频率分布的地区差异。采用PCR-SSP分型技术对420名中国北方汉族人群HLA-Cw*位点进行高分辨基因分型,并对其分布规律进行统计学分析。结果表明:共检出30个HLA-Cw*等位基因,分布频率最高的有Cw*0102;0702;0602(0.1776;0.1217;0.1150),其他频率较高的等位基因依次为Cw*0304,0801,0303,0302,0401,1402。首次在该人群中检测到HLA-Cw*0506,0810,1510,1601和1701较少见等位基因。统计分析表明,HLA-Cw位点基因型分布符合Hardy-Weinberg平衡(p0.05)。结论:采用高分辨等位基因分型,可准确了解HLA-Cw*位点等位基因在我国北方汉族群体中的分布规律和特征,为HLA-Cw*座位的相关研究提供了依据。
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| 关 键 词： | HLA-Cw^＊位点 高分辨基因分型 等位基因频率 遗传多态性 |
Frequencies of High-resolution HLA-Cw* Alleles in China Northern Han Population |
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| LIANG Xiao-Lan,HAN Jun-Ling,LI-Qian,SUN Le-Jing,DU-Ying,LIU Lan-Ting,QIU Lu-Gui, Union Stem Cell & Gene Engineering Co.,Ltd.,Tianjin Cord Blood Bank,Tianjin ,China.Frequencies of High-resolution HLA-Cw* Alleles in China Northern Han Population[J].Journal of Experimental Hematology,2010,18(2):486-489. |
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| Authors: | LIANG Xiao-Lan HAN Jun-Ling LI-Qian SUN Le-Jing DU-Ying LIU Lan-Ting QIU Lu-Gui Union Stem Cell & Gene Engineering Co Ltd Tianjin Cord Blood Bank Tianjin China |
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| Institution: | LIANG Xiao-Lan1,2,HAN Jun-Ling1,LI-Qian1,SUN Le-Jing1,DU-Ying1,LIU Lan-Ting1,QIU Lu-Gui1,2 1Union Stem Cell & Gene Engineering Co.,Ltd.,Tianjin Cord Blood Bank,Tianjin 300384,China,2Institute of Hematology,Hospilal of Blood Disease,Chinese Academy of Medical Sciences & Peking Union Medical College,Tianjin 300020 |
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| Abstract: | This study was purposed to investigate the frequencies of HLA-Cw*loci in China Northern Han population at gene level and to analyze the population genetic characteristics of HLA-Cw* alleles and distribution difference of gene frequency in regions.The high resolution genotyping for HLA-Cw*loci of 420 cases in China Northern Han population was performed by using PCR-SSP typing technique and their distribution regularity was analyzed statistically.The results showed that 30 HLA-Cw*alleles were detected,among w... |
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| Keywords: | HLA-Cw* loci high-resolution genotyping allele frequency genetic polymorphism |
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