| UP－REGULATION OF CYCLOOXYGENASE－2 GENE EXPRESSION CORRELATES WITH TUMOR ANGIOGENESIS IN HUMAN BREAST CANCER |
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| 引用本文： | 代志军,王西京,刘小旭,康华峰,姜建涛,管海涛,张淑群,薛兴欢,薛锋杰.UP－REGULATION OF CYCLOOXYGENASE－2 GENE EXPRESSION CORRELATES WITH TUMOR ANGIOGENESIS IN HUMAN BREAST CANCER[J].中国癌症研究,2003,15(2):149-151. |
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| 作者姓名： | 代志军 王西京 刘小旭 康华峰 姜建涛 管海涛 张淑群 薛兴欢 薛锋杰 |
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| 作者单位： | Department of Oncology,Second Hospital,Xi'an Jiaotong University,Department of Oncology,Second Hospital,Xi'an Jiaotong University,Department of Oncology,Second Hospital,Xi'an Jiaotong University,Department of Oncology,Second Hospital,Xi'an Jiaotong University,Department of Oncology,Second Hospital,Xi'an Jiaotong University,Department of Oncology,Second Hospital,Xi'an Jiaotong University,Department of Oncology,Second Hospital,Xi'an Jiaotong University,Department of Oncology,Second Hospital,Xi'an Jiaotong University,Department of Oncology,Second Hospital,Xi'an Jiaotong University Xi' 710004,Xi' 710004,Xi' 710004,Xi' 710004,Xi' 710004,Xi' 710004,Xi' 710004,Xi' 710004,Xi' 710004 |
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| 摘 要： | Prostaglandins(PGs) play a critical role in tumor development and growth by regulating numerous biologic processes, including tumor angiogenesis1]. Cyclooxygenase-2 (COX-2) is an inducible enzyme that converts arachidonic acid to PGs. Overexpression of the COX-2 gene in mammary glands of transgenic mice was sufficient to induce tumorigenesis2]. COX-2expression may contribute to the synthesis of PGs, which have been related to carcinogenesis and tumor progression. Recent studies have sh…
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| 关 键 词： | 环氧合酶－2 基因表达 乳腺癌 微血管密度 血管内皮生长因子 |
| 收稿时间： | 14 August 2006 |
Up-regulation of cyclooxygenase-2 gene expression correlates with tumor angiogenesis in human breast cancer |
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| Dai?Zhi-jun?Email author,Wang?Xi-jing,Liu?Xiao-xu,Kang?Hua-feng,Jiang?Jina-tao,Guan?Hai-tao,Zhang?Shu-qun,Xue?Xing-huan,Xue?Feng-jie.Up-regulation of cyclooxygenase-2 gene expression correlates with tumor angiogenesis in human breast cancer[J].Chinese Journal of Cancer Research,2003,15(2):149-151. |
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| Authors: | Email author" target="_blank">Dai?Zhi-jun?Email author Wang?Xi-jing Liu?Xiao-xu Kang?Hua-feng Jiang?Jina-tao Guan?Hai-tao Zhang?Shu-qun Xue?Xing-huan Xue?Feng-jie |
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| Institution: | (1) Department of Oncology, Second Hospital, X’ian Jiaotong University, 710004 Xi’an |
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| Abstract: | Objective: To study the relationship between cyclooxygenase-2 (COX-2) expression and tumor angiogenesis in human breast cancer. Methods: Archival primary breast carcinomas (n = 62), adjacent ductal carcinoma in situ (DCIS, n = 13) and DCIS alone (n = 5) were analyzed for COX-2 and VEGF expression by immunohistochemistry using specific monoclonal antibodies. Microvessel density (MVD) was also examined the using CD34 staining. Results: A significant correlation was found between COX-2 and VEGF expression (P<0.01). Both COX-2 and VEGF were significantly correlated with MVD (P<0.05) and P<0.01, respectively). COX-2 and VEGF genes were overexpressed in tumor specimens as compared with normal epithelia. Conclusion: COX-2 is related to tumor angiogenesis in breast cancer. It is likely that VEGF is one of the most important mediators of the COX-2 angiogenic pathway. |
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| Keywords: | Breast carcinoma Cyclooxygenase-2 VEGF Microvessel density |
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