| EXPRESSION OF PHOSPHO-b-CATENIN AND ITS SIGNIFICANCE IN NON-SMALL CELL LUNG CANCER |
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| 作者姓名： | 林东 王恩华 张志坤 徐洪涛 李庆昌 邱雪杉 |
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| 作者单位： | Department of Pathology，College of Basic Medical Science，China Medical University，Department of Pathology，College of Basic Medical Science，China Medical University，Department of Pathology，College of Basic Medical Science，China Medical University，Department of Pathology，College of Basic Medical Science，China Medical University，Department of Pathology，College of Basic Medical Science，China Medical University，Department of Pathology，College of Basic Medical Science，China Medical University Shenyang 110001，Shenyang 110001，Shenyang 110001，Shenyang 110001，Shenyang 110001，Shenyang 110001 |
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| 基金项目： | This work was supported by the grants for studied abroad and returned scholars from Ministry of Education of China (No. 2002-247). * |
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| 摘 要： | b-catenin is a 92kDa soluble protein and arecognized component of a cell-cell adhesion regulator when coupled with cadherin1] and is also considered to play an important role as a member in the Wingless/Wnt signal transduction pathway2]. Combined type b-catenin combines with plasma zone of E-cad and mediatehomotypic cell-cell adhesion; free cytoplasmic typeb-catenin, Wnt protein, GSK-3b, APC and Axin etc.form Wnt signal transduction pathway. Cytoplasmic type b-catenin forms multiprotein …
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EXPRESSION OF PHOSPHO-b-CATENIN AND ITS SIGNIFICANCE IN NON-SMALL CELL LUNG CANCER |
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| LIN Dong,WANG En-hua,ZHANG Zhi-kun,XU Hong-tao,LI Qing-chang,QIU Xue-shan.EXPRESSION OF PHOSPHO-b-CATENIN AND ITS SIGNIFICANCE IN NON-SMALL CELL LUNG CANCER[J].Chinese Journal of Cancer Research,2003(1). |
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| Authors: | LIN Dong WANG En-hua ZHANG Zhi-kun XU Hong-tao LI Qing-chang QIU Xue-shan |
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| Institution: | LIN Dong,WANG En-hua,ZHANG Zhi-kun,XU Hong-tao,LI Qing-chang,QIU Xue-shan Department of Pathology,College of Basic Medical Science,China Medical University,Shenyang 110001 |
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| Abstract: | Objective: To investigate phospho-b-catenin expression in non-small cell lung cancer (NSCLC) and to study the relationship between phospho-b-catenin expression and some clinical pathological factors. Methods: The expression of phospho-b-catenin in 67 primary NSCLC cases detected immunohistochemically. Results: phospho- b-catenin was not expressed in normal bronchial mucous cell and showed cytoplasmic and nuclear expression in NSCLC cell. Total positive expression rate reached 62.7%, and positive expression rate of nucleus was 38.8%. The positive expression rate (87.5%) and nuclear expression rate of adenocarcinoma (62.5%) were apparently higher than those of squamous cell cancer (40.0% and 17.1%) (P<0.01). Expression of phospho-b-catenin had no relationship to differentiation degree and lymphatic metastasis. The postoperative survival time is not related to phospho-b- catenin expression. (Log-rank test, P=0.9198; P=0.6274). COX model analysis showed that tumor stage and differentiation are independent risk factors to prognosis (P=0.001; P=0.020). Conclusion: NSCLC cells show positive expression of phospho-b-catenin, phospho-b-catenin nuclear expression is relevant to histological types. There is no difference in postoperative survival time between patients with phospho-b-catenin positive expression and patients with negative expression, expression of phospho-b- catenin is not independent risk factor to prognosis. |
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| Keywords: | Phosphorylation b-catenin Non-small cell lung cancer Prognosis |
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