| Abstract: | Objective: To observe the effect of inhibition oftelomerase activity by selenium dioxide (SeO2) on lungcarcinoma cell line GLC-82. Methods: TRAP-PCR-ELISA was used to study the changes of telomerase activity inhuman pulmonary adenocarcinoma cell line GLC-82 treated by SeO2 at the different concentrations (3, 10, 30 mmol/L) and for different times (24, 48, and 72 h). Results: SeO2inhibited the telomerase activity of GLC-82 at the different concentrations after treatment of 24, 48 and 72 h.Conclusion: SeO2 inhibits from telomerase activity ofhuman lung carcinoma line GLC-82. The effect of inhibition is dose-dependant and time-dependant. |
