| EFFECTS OF SeO_2 ON REGULATORY REGIONS p250 OF c-fos GENE |
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| 引用本文： | 于海建,曹晓哲,龙芸,赵梅兰. EFFECTS OF SeO_2 ON REGULATORY REGIONS p250 OF c-fos GENE[J]. 中国癌症研究, 2003, 15(1) |
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| 作者姓名： | 于海建 曹晓哲 龙芸 赵梅兰 |
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| 作者单位： | Department of Respiratory Diseases，Peking Union Medical College Hospital，Peking Union Medical College & Chinese Academy of Medical Sciences，Institute of Radiation Medicine，Academy of Military Medical Sciences，Department of Respiratory Diseases，Peking Union Medical College Hospital，Peking Union Medical College & Chinese Academy of Medical Sciences，Institute of Radiation Medicine，Academy of Military Medical Sciences Beijing 100730，Beijing 100850，Beijing 100730，Beijing 100850 |
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| 摘 要： | The element selenium was recognized 40 years ago as being essential in the nutrition of animal and humans and it is an essential component of a number of enzymes present in the amino acid selenocysteine (Se-Cys). Selenium has also been shown to inhibit tumorigenesis in both animal models and humans[1]. Supplementing with selenium in diets may reduce the human cancer risk[2]. It has been reported that cell protein kinase cdk2 andprotein kinase C were strongly inhibited by various forms of sel…
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EFFECTS OF SeO2 ON REGULATORY REGIONS p250 OF c-fos GENE |
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| YU Hai-jian,CAO Xiao-zhe ,LI Long-yun ,ZHAO Mei-lan. EFFECTS OF SeO2 ON REGULATORY REGIONS p250 OF c-fos GENE[J]. Chinese Journal of Cancer Research, 2003, 15(1) |
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| Authors: | YU Hai-jian CAO Xiao-zhe LI Long-yun ZHAO Mei-lan |
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| Affiliation: | YU Hai-jian,CAO Xiao-zhe *,LI Long-yun 1,ZHAO Mei-lan 2 1Department of Respiratory Diseases,Peking Union Medical College Hospital,Peking Union Medical College & Chinese Academy of Medical Sciences,Beijing 100730 2Institute of Radiation Medicine,Academy of Military Medical Sciences,Beijing 100850 |
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| Abstract: | Objective: This study was designed to determinewhether regulatory regions p250 of c-fos gene wereresponsive to SeO2 and to seek the possible mechanisms of regulation. Methods: HeLa cells were transfected withplasmids p250-tk CAT containing upstream regulatingregions of c-fos gene. Cells were treated by SeO2 for 20 min. CAT expression in transfected cells was observed by thinlayered chromatography. Results: In transfected HeLa cells CAT expression showed obvious increase after exposure to SeO2, especially in 10 mmol/L and 30 mmol/L group (P<0.05). Conclusion: Through affecting regulatory regions p250 of c-fos gene, SeO2 exerted biological effect on tumor cells. SeO2possibly had anti-tumor effects. |
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| Keywords: | SeO2 c-fos gene p250 |
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