氯沙坦与赖诺普利对大鼠压力负荷性心血管重构的影响

目的：探讨心血管重构的结构、功能改变以及氯沙坦和赖诺普利的干预作用。方法：膈下腹主动脉缩窄法建立大鼠心肌肥厚模型。检测各实验组平均动脉压（mean avterial pressure,MAP)、心肌肥厚程度、胸主动脉内皮功能。结果：与假手术组相比，模型组MAP、左室重量（left ventricular weight,LVW)、左室重量指数（left venticuler mess index,LVMI)、心肌细胞横径（transverse diameter of myocardium,TDM)分别提高28．6％、20．5％、26．9％、17．9％（P＜0．01），胸主动脉环对乙酰胆碱（ACh)血管舒张反应明显降低（P＜0．01）；降压剂量氯沙坦与赖诺普利与非降压剂量氯沙坦干预后，能完全预防心肌肥厚，使胸主动脉环对ACh血管舒张反应正常化，以降压剂量氯沙坦作用最为明显；非降压剂量赖诺普利能改善心肌肥厚程度，但与假手术组有差异（P＜0．01），胸主动脉环对ACh血管舒张反应无改善。六组动物胸主动脉环对硝普钠（SNP）最大舒张反应均无差别，模型组反应曲线右移。结论：氯沙坦与赖诺普利能预防心肌肥厚，改善内皮功能，与剂量有一定关系。

Effect of losartan and lisinopril on cardiovascular remodelling and vascular function in pressare overload rats

Objective: To investigate the stractural and functioal changes of cardiovascular remodelling in pressure overload rats and examine the preventive effects of losartan on them. Methods: Pressure overload model was produced by abdominal aortic coarctation in rats. Mean arterial pressure (MAP) and data of my-ocardial hypertrophy were measured in groups. In addition the vascular reactivity to acetylcholine (ACh) and sodium nitroprusside (SNP) was studied by using rings of thoracic. Results: As compared with Group Sham, Group model rats manifested myocardial hypertrophy. Their MAP, LVW,LVWI and TDM were 28. 6 % , 20. 5 % , 26.9 % and 17.9 % increased respectively (P < 0.01). The vascular relaxation response to ACh in Group model was decreased significantly (P<0.01). Under the interference of of lisinopril and losartan and sub-hypotensive losartan, myocardial hypertrophy may be completely prevented and the vascular relaxation response to ACh was improved. The effect of hypotensive dose losartan was most prominent. Sub-hypotensive dose lisinopril alleviated cardiovascular remodelling but did not improve vascular relaxarion response to ACh. The maximal vascular relaxation response to SNP was similar among 6 groups. The total response curve shifted to right in Group model. Conclusion: Lisinopril and losartan could prevent cardiovascular remodelling and improve vascular endothelial function,however, it is dose-dependent.