| 阿尔茨海默病患者血-脑屏障功能障碍神经影像学研究进展 |
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| 引用本文： | 徐琴,柏峰.阿尔茨海默病患者血-脑屏障功能障碍神经影像学研究进展[J].中国现代神经疾病杂志,2017(6):462-466. |
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| 作者姓名： | 徐琴 柏峰 |
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| 作者单位： | 1. 东南大学医学院, 南京,210009;2. 东南大学附属中大医院神经内科, 南京,210009 |
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| 基金项目： | 国家自然科学基金重大研究计划项目(项目编号:91332104)This study was supported by Major Research Project of National Natural Science Foundation of China(91332104) |
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| 摘 要： | 近年研究表明血-脑屏障功能障碍在认知功能障碍和痴呆的病理生理学机制中扮演重要角色。血-脑屏障可以调节脑微环境稳态,调控营养物质(如葡萄糖和氨基酸)转运,阻止血源性产物、病原体和神经毒性物质进入脑组织。神经影像学技术可以实现血-脑屏障完整性破坏的定位和定量分析,为阐明阿尔茨海默病发病机制提供新的切入点。
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| 关 键 词： | 阿尔茨海默病 血脑屏障 磁共振成像 综述 |
Research progress of neuroimaging of blood-brain barrier breakdown in Alzheimer's disease patients |
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| XU Qin,BAI Feng.Research progress of neuroimaging of blood-brain barrier breakdown in Alzheimer's disease patients[J].Chinese Journal of Contemporary Neurology and Neurosurgery,2017(6):462-466. |
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| Authors: | XU Qin BAI Feng |
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| Abstract: | Recent studies indicate that blood-brain barrier (BBB) breakdown may play an important role in the pathophysiology of cognitive dysfunction and dementia.BBB regulates the homeostasis of brain microenvironment,controls the transfer of required nutrients (e.g.,glucose and amino acids),and limits entry of blood-derived products,pathogens and neurotoxins into the brain tissue.Recent advances in neuroimaging techniques offer new possibilities to realize positioning and quantitative detection of BBB disruption.It provides a new insertion point for elucidating the pathogenesis of Alzheimer's disease (AD). |
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| Keywords: | Alzheimer disease Blood-brain barrier Magnetic resonance imaging Review |
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