垂体腺瘤侵袭及复发相关因素研究进展

垂体腺瘤作为临床常见的中枢神经系统内分泌肿瘤,多呈良性,部分具有侵袭性、易复发,是神经外科亟待解决的难题。其临床预后主要受生物学因素和临床因素的影响,生物学因素方面,随着阵列技术等分子病理学的应用,以及对垂体腺瘤病因学与肿瘤进展,不同亚型垂体腺瘤基因表达调控研究的深入,筛选出多种预测性、诊断分型和治疗相关预测因子和基因;临床因素方面,规范的诊断与治疗流程以及新技术的应用明显改善垂体腺瘤预后。本文拟就生物学因素和临床因素与垂体腺瘤侵袭和复发的研究进展进行简要综述。

Advances in research of invasion and recurrence of pituitary adenoma

Pituitary adenoma,a common intracranial neuroendocrine tumor is usually a benign tumor,some of which are of invasiveness and high recurrence,making it a problem to be solved in neurosurgery.The clinical prognosis of pituitary adenoma is mainly determined by biological factors and clinical factors.In terms of biological factors,with the application of molecular array technology and others molecular detection progress in etiology and pathology,a lot of prediction,diagnosis,treatment related predictive factors and genes are detected for further screening.As for the other factors,standardized prognosis and treatment procedure and application of new technology are obvious in improving the prognosis of pituitary adenomas.This article reviews the research progress of the factors of pituitary adenoma,and provides the reference for the diagnosis and treatment of pituitary adenoma.