荧光膀胱镜下膀胱肿瘤电切术治疗非肌层浸润性膀胱癌的效果观察

目的 观察荧光膀胱镜下膀胱肿瘤电切术(transurethral resection of bladder tumor,TURBT)治疗非肌层浸润性膀胱癌的临床效果.方法 57例非肌层浸润性膀胱癌患者根据所使用的膀胱镜的不同分为两组:白光膀胱镜组(n=30),采用白光膀胱镜下TURBT治疗;荧光膀胱镜组(n=27),采用荧光膀胱镜下TURBT治疗.比较两组的临床一般资料、手术相关指标及术后3、6、12及18个月不同时间点的复发率.结果 两组患者在性别、年龄、肿瘤数目、病理分期及病理分级等方面比较,差异无统计学意义(P>0.05);两组患者的手术时间、术中出血量、留置导管时间及术后住院时间等手术相关指标比较,差异亦无统计学意义(P>0.05);荧光膀胱镜组术后3、6、12及18个月不同时间点的复发率均明显低于白光膀胱镜组(P<0.05). 结论 荧光膀胱镜下TURBT治疗非肌层浸润性膀胱癌可明显降低术后早期复发率.

Clinical observation of transurethral resection of bladder tumor with fluorescence cystoscope in the treat-ment of non-muscle-invasive bladder cancer

Objective To observe the clinical effect of transurethral resection of bladder tumor (TURBT)with fluorescence cystoscopy in the treatment of non-muscle-invasive bladder cancer. Methods Fifty-seven patients with non-muscle-invasive bladder cancer were divided into two groups according to the choice of different cystoscopies.White light cystoscopy group (n = 30 cases)were treated with TURBT guided by white light cystoscopy,while fluorescence cystoscopy group (n =27 cases)were treated with TURBT guided by fluorescence cystoscopy.The clinical data,operative in-dexes and recurrence rate at different time points such as 3,6,12 and 18 months after operation be-tween the two groups were compared. Results There was no significant difference between the two groups about gender,age,tumor number,pathological staging and pathological grading (P >0.05).There was no significant difference between the two groups about the operative time,bleeding volume,indwelling catheter time and postoperative hospital stay (P >0.05).The recurrence rates in different time points such as 3,6,12 and 18 months after operation of the fluorescence cystoscopy group were significantly lower than those of white light cystoscopy group (P <0.05). Conclusions The treatment of TURBT guided by fluorescence cystoscopy for non-muscle-invasive bladder canc-er can significantly reduce the early recurrence rate.