| 顶空气相色谱法测定氟[~(18)F]脱氧葡糖注射液中有机溶剂残留量 |
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| 引用本文： | 王庆芬,杨丽娜,倪晓霞,林跃松,刘威宏.顶空气相色谱法测定氟[~(18)F]脱氧葡糖注射液中有机溶剂残留量[J].西北药学杂志,2017(4):465-467. |
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| 作者姓名： | 王庆芬 杨丽娜 倪晓霞 林跃松 刘威宏 |
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| 作者单位： | 解放军第一七五医院/厦门大学附属东南医院,漳州,363000 |
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| 摘 要： | 目的建立顶空气相色谱法测定氟~(18)F]脱氧葡糖注射液中3种有机溶剂残留量的方法。方法采用顶空毛细管气相色谱法,Thermo TG-WAXMS毛细管柱(30m×0.25mm,0.5μm),以氮气为载气,采用氢火焰检测器(FID)为检测器,程序升温:初始50℃,维持8min,以30℃·min-1升温至130℃,保持2min。结果乙醇、丙酮和乙腈3种有机溶剂均达到完全分离,在考察的质量浓度范围内线性关系均良好,高、中、低3种质量浓度的回收率为97.6%~99.0%。结论该方法灵敏度、准确度均达到有机溶剂残留量的检测要求,可用于氟~(18)F]脱氧葡糖注射液中3种有机溶剂残留量的检测和分析。
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| 关 键 词： | 氟[18F]脱氧葡糖注射液 有机溶剂残留 顶空气相色谱法 |
Determination of residual organic solvents in Fludeoxyglucose [18F] Injections by headspace gas chromatography |
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| WANG Qingfen,YANG Li′na,NI Xiaoxia,LIN Yuesong,LIU Weihong.Determination of residual organic solvents in Fludeoxyglucose [18F] Injections by headspace gas chromatography[J].Northwest Pharmaceutical Journal,2017(4):465-467. |
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| Authors: | WANG Qingfen YANG Li′na NI Xiaoxia LIN Yuesong LIU Weihong |
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| Abstract: | Objective To establish a headspace gas chromatography method for the determination of residual organic solvents (ethanol,acetone and acetonitrile) in Fludeoxyglucose 18F] Injections.Methods Headspace gas chromatography was adopted using a Thermo TG-WAXMS capillary column (30 m×0.25 mm,0.5 μm) with nitrogen as the carrier gas and flame ionization detector (FID) as the detector.The initial column temperature was set at 50 ℃,maintained for 8 min,and then raised (30 ℃·min-1) to 130 ℃,and maintained for another 2 min.Results The 3 residual organic solvents (ethanol,acetone and acetonitrile) were completely separated.A good linearity in the experimental concentration was observed.The average recoveries were between 97.6%-99.0%.Conclusion The method is sensitive and accurate,and can be used for the determination of 3 residual organic solvents in Fludeoxyglucose 18F] Injections. |
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| Keywords: | Fludeoxyglucose [18F] Injections residual organic solvents headspace gas chromatography |
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