| 一氧化氮在糖尿病大鼠合并肾病中的变化及意义 |
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| 引用本文： | 王柏欣,孟德欣,齐淑芳,王伟群.一氧化氮在糖尿病大鼠合并肾病中的变化及意义[J].黑龙江医药科学,2004,27(1):15-15. |
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| 作者姓名： | 王柏欣 孟德欣 齐淑芳 王伟群 |
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| 作者单位： | 佳木斯大学基础医学院,黑龙江,佳木斯,154007;佳木斯大学基础医学院,黑龙江,佳木斯,154007;佳木斯大学基础医学院,黑龙江,佳木斯,154007;佳木斯大学基础医学院,黑龙江,佳木斯,154007 |
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| 摘 要： | 目的 :观察一氧化氮 (NO)在糖尿病大鼠合并肾病中的变化及意义。方法 :复制糖尿病肾病病变 (DN)大鼠模型 ,采用硝酸还原酶法测定尿液及肾组织匀浆中 NO含量。结果 :尿液中 NO含量变化为糖尿病肾病组高于正常组 (NC组 )(P<0 .0 1) ,而治疗组 (INS组 )与 DN组比较两组间无差异 (P >0 .0 5 ) ;肾组织匀浆中 NO含量变化为 DN组高于 NC组(P<0 .0 1) ,而 INS组高于 DN组 (P <0 .0 1)。结论 :NO在介导 DN的肾小球高滤过中有重要作用
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| 关 键 词： | NO 糖尿病肾病 动物实验 |
| 文章编号： | 1008-0104(2004)01-0015-01 |
| 修稿时间： | 2003年10月23 |
The changes of NO density in rats with diabetic nephropathy |
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| WANG Bai-xin,MENG De-xin,QI Shu-fang,WANG Wei-qun.The changes of NO density in rats with diabetic nephropathy[J].Heilongjiang Medicine and Pharmacy,2004,27(1):15-15. |
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| Authors: | WANG Bai-xin MENG De-xin QI Shu-fang WANG Wei-qun |
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| Abstract: | Objective: To investigate the changes in NO density in rats with diabetic nephropathy(DN). Methods: We prepared DN models, and detected the concentration of NO in urine and kidney homogenate by nitrate reductase method. Results: The concentration of NO was higher in DN rats compared with that in normal group (NC group) (P<0.01) and there was no notable difference between INS group and DN group (P>0.05) in urine samples. In kidney homogenate samples, the concentration of NO in DN group was higher than in NC group (P<0.01), but NO density in INS group was higher than in DN group (P<0.01). Conclusions: NO is an important factor in renal glomerulus high filteration. |
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| Keywords: | NO diabetic nephropathy animal experiment |
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