Decreased medial temporal lobe activation in BDNF Met allele carriers during memory encoding |
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| Authors: | Karolina Kauppi Lars-Göran Nilsson Rolf Adolfsson Anders Lundquist Elias Eriksson Lars Nyberg |
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| Institution: | 1. Department of Integrative Medical Biology (Physiology) Umeå University, SE-90187, Umeå, Sweden and Umeå Center for Functional Brain Imaging (UFBI), Umeå, Sweden;2. Department of Psychology and Stockholm Brain Institute, Stockholm University, 106 91 Stockholm, Sweden;3. Department of Clinical Sciences, Psychiatry, Umeå University, SE-90185 Umeå, Sweden;4. Department of Statistics, Umeå University, SE-90187 Umeå, Sweden;5. Department of Pharmacology, Institution of Neuroscience & Physiology, Gothenburg University, Sahlgrenska Academy, S-40530 Gothenburg, Sweden;6. Department of Radiation Sciences (Diagnostic Radiology), Umeå University, SE-90187 Umeå, Sweden |
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| Abstract: | The Met allele of the Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism has been associated with impaired activity-dependent secretion of BDNF protein and decreased memory performance. Results from imaging studies relating Val66Met to brain activation during memory processing have been inconsistent, with reports of both increased and decreased activation in the Medial Temporal Lobe (MTL) in Met carriers relative to Val homozygotes. Here, we extensively studied BDNF Val66Met in relation to brain activation and white matter integrity as well as memory performance in a large imaging (n=194) and behavioral (n=2229) sample, respectively. Functional magnetic resonance imaging (fMRI) was used to investigate MTL activation in healthy participants in the age of 55–75 years during a face-name episodic encoding and retrieval task. White matter integrity was measured using diffusion tensor imaging. |
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| Keywords: | Imaging Genetics Memory Val66Met Parahippocampus |
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