In vitro effects of ambroxol on Cryptococcus adherence,planktonic cells,and biofilms |
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| Authors: | Qingtao Kong Xue Du Suyang Huang Rui Yang Chengzhen Zhang Yongnian Shen Weida Liu Hong Sang |
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| Affiliation: | 1. Southern Medical University, Guangzhou, China;2. Department of Dermatology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China;3. Department of Dermatology, Third Hospital of Hangzhou, Hangzhou, China;4. Department of Mycology, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China |
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| Abstract: | The antifungal effects of ambroxol (Amb; the metabolite VIII of bromhexine) against Cryptococcus planktonic cells and mature biofilms were investigated in this study. Amb showed antifungal activity against planktonic cells and mature biofilms. Disk diffusion test similarly showed antifungal profile for planktonic cells. Furthermore, Amb was found to be synergetic with fluconazole against planktonic cells and reduced the adherence of cells to polystyrene. Our results suggest that Amb can inhibit cryptococcal cells and biofilms, indicating its potential role in the prevention and treatment of cryptococcosis. |
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| Keywords: |
Cryptococcus
fluconazole ambroxol anti‐cryptococcal activity |
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