IFI16 reduced expression is correlated with unfavorable outcome in chronic lymphocytic leukemia |
| |
| Authors: | Pier Paolo Piccaluga Claudio Agostinelli Simona Righi Maria Ciccone Maria Carla Re Giuseppina Musumeci Erica Diani Caterina Signoretto Isabella Bon Ottavio Piccin Antonio Cuneo Claudio Tripodo Cristina Ponti Donato Zipeto Santo Landolfo Davide Gibellini |
| |
| Affiliation: | 1. Department of Experimental, Diagnostic, and Specialty Medicine, University of Bologna, Bologna, Italy;2. Section of Genomics and Personalized Medicine, Istituto Euro‐Mediterraneo di Scienza e Tecnologia (IEMEST), Palermo, Italy;3. Department of Biomedical Sciences, Hematology Section, S. Anna Hospital, University of Ferrara, Ferrara, Italy;4. Department of Experimental, Diagnostic, and Specialty Medicine, Microbiology Unit, University of Bologna, Bologna, Italy;5. Department of Diagnostic and Public Health, Unit of Microbiology, University of Verona, Verona, Italy;6. Department of Experimental, Diagnostic, and Specialty Medicine, Otolaryngology Unit, University of Bologna, Bologna, Italy;7. Department of Human Pathology, University of Palermo, Palermo, Italy;8. Department of Life Sciences, University of Trieste, Trieste, Italy;9. Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy;10. Department of Public Health and Microbiology, University of Turin, Turin, Italy |
| |
| Abstract: | Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults. Its clinical course is typically indolent; however, based on a series of pathobiological, clinical, genetic, and phenotypic parameters, patient survival varies from less than 5 to more than 20 years. In this paper, we show for the first time that the expression of the interferon‐inducible DNA sensor IFI16, a member of the PYHIN protein family involved in proliferation inhibition and apoptosis regulation, is associated with the clinical outcome in CLL. We studied 99 CLLs cases by immunohistochemistry and 10 CLLs cases by gene expression profiling. We found quite variable degrees of IFI16 expression among CLLs cases. Noteworthy, we observed that a reduced IFI16 expression was associated with a very poor survival, but only in cases with ZAP70/CD38 expression. Furthermore, we found that IFI16 expression was associated with a specific gene expression signature. As IFI16 can be easily detected by immunohistochemistry or flow cytometry, it may become a part of phenotypic screening in CLL patients if its prognostic role is confirmed in independent series. |
| |
| Keywords: | IFI16 chronic lymphocytic leukemia ZAP70 prognosis gene expression immunohistochemistry |
|
|
