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Transplantation of multipotent astrocytic stem cells into a rat model of neonatal hypoxic-ischemic encephalopathy |
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| Authors: | Zheng Tong Rossignol Candace Leibovici Avital Anderson Kevin J Steindler Dennis A Weiss Michael D |
| Institution: | McKnight Brain Institute, University of Florida, Gainesville, FL, USA. |
| Abstract: | Hypoxic-ischemic encephalopathy (HIE) in neonates results in long-term disabilities. Stem cell therapy may offer an attractive treatment for HIE. Multipotent astrocytic stem cells (MASCs) from mice transplanted into a rat model of hypoxia-ischemia (HI) survived the transplantation and showed signs of migration towards the injured cortex. Some MASCs around the injured cortex differentiated into neuronal and astrocytic phenotypes. MASCs transplanted into non-ischemic pups survived but retained their astrocytic phenotype. These data suggest that transplanted MASCs can survive and differentiate into neurons and astrocytes in the post-injury milieu of the neonatal brain injured by HI. |
| Keywords: | HIE hypoxic-ischemic encephalopathy MASCs multipotent astrocytic stem cells CNS central nervous system SEZ subependymal zone FBS fetal bovine serum GFP green fluorescence protein PBS phosphate-buffered saline RMS rostral migratory stream OB olfactory bulb BDNF brain-derived neurotrophic factor |
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