| 甘康冲剂对D-半乳糖胺诱导小鼠化学性肝损伤的保护作用 |
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| 引用本文： | 王迪生. 甘康冲剂对D-半乳糖胺诱导小鼠化学性肝损伤的保护作用[J]. 中国实验方剂学杂志, 2006, 12(10): 58-60 |
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| 作者姓名： | 王迪生 |
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| 作者单位： | 安徽蚌埠医学院第二附属医院,安徽,蚌埠,233040 |
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| 摘 要： | 目的:探讨甘康冲剂对D-半乳糖胺(D-GalN)致小鼠急性化学性肝损伤的保护作用及可能机制。方法:建立D-GalN诱导小鼠化学性肝损伤模型,分光光度法检测血清中ALT、AST水平和肝匀浆中MDA、NO含量。结果:甘康(200,400和800mg.kg-1)灌胃给药一周均能降低血清中升高的转氨酶水平,使升高的肝脾指数降低;同时发现甘康可降低肝匀浆中升高的MDA和NO水平。结论:甘康颗粒剂对D-GalN致小鼠急性化学性肝损伤具有保护作用,其机制与抗肝细胞氧化等有关。
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| 关 键 词： | 甘康 肝损伤 D-半乳糖胺 |
| 文章编号： | 1005-9903(2006)10-0058-03 |
| 收稿时间： | 2006-02-15 |
| 修稿时间： | 2006-02-15 |
Protective Effects of Gankang on Chemical Liver Injury Induced by D-galactosamine in Mice |
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| WANG Di-sheng. Protective Effects of Gankang on Chemical Liver Injury Induced by D-galactosamine in Mice[J]. China Journal of Experimental Traditional Medical Formulae, 2006, 12(10): 58-60 |
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| Authors: | WANG Di-sheng |
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| Affiliation: | The Second Hospital Affiliated to Bengbu Medical College,Anhui,Bengbu 233040,China |
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| Abstract: | Objective:To investigate the protective effects of Gankang on D-galactosamine-induced liver injury and study its possible mechanism.Methods:The model of chemical injury in liver of mouse was prepared.The level of alanine aminotransferase(ALT),aspartate aminotransferase(AST) in serum,malondiadehyde(MDA)content,nitric oxide(NO)in liver homogenate were assayed by spectrophotometer.Results:Gankang(200,400,800mg·kg-1significantly decreased the levels of serum transaminase(ALT,AST),liver index and spleen index.Furthermore,Gankang also decreased MDA and NO level in liver homogenate.Conclusion:Gankang possesses protective action on chemical injury in liver of mice,which is related to its mechanism of ressistance to the liver cell oxidation. |
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| Keywords: | Gankang Chemical liver injury D-GaiN |
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