Mapping of DFNB12, a gene for a non-syndromal autosomal recessive deafness, to chromosome 10q21-22 |
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Authors: | Chaib H; Place C; Salem N; Dode C; Chardenoux S; Weissenbach J; el Zir E; Loiselet J; Petit C |
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Institution: | Unite de Genetique Moleculaire Humaine, URA CNRS 1968, Institut Pasteur, Paris, France. |
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Abstract: | We report here, the localization of a new recessive non-syndromal deafness
gene (DFNB12) to 10q21-22 by linkage analysis, of a Sunni family. Affected
individuals suffer from congenital profound sensorineural hearing loss. A
maximum LOD score of 6.40 (theta = 0.00) was obtained with locus D10S535.
Analysis of patients carrying recombinations mapped the gene distal to
D10S529 and proximal to D10S532, delineating an interval between 11 and 15
cM. Three deaf mouse mutants Jackson circler (jc), Waltzer (v) and Ames
waltzer (av) have been localized to the homologous murine region on
chromosome 10. Each of these mouse mutants is a candidate mouse model for
the DFNB12- associated hearing impairment.
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