| 叶黄素对D-半乳糖致小鼠氧化损伤的保护作用 |
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| 引用本文： | 麦嘉仪,沈新南,魏延,吴岷,姚国英.叶黄素对D-半乳糖致小鼠氧化损伤的保护作用[J].中国预防医学杂志,2010(4):346-349. |
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| 作者姓名： | 麦嘉仪 沈新南 魏延 吴岷 姚国英 |
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| 作者单位： | 复旦大学公共卫生学院营养与食品卫生学教研室; |
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| 摘 要： | 目的研究不同剂量叶黄素对D-半乳糖(D-gal)小鼠氧化应激损伤的影响。方法44只昆明种小鼠随机分为D-gal模型对照组、叶黄素低剂量组、叶黄素高剂量组和正常对照组。D-gal120 mg/(kg.d)腹腔注射制作小鼠氧化应激模型,叶黄素低、高剂量组分别灌胃给予叶黄素10 mg/(kg.d)、40 mg/(kg.d),持续6周。检测小鼠肝组织活性氧(ROS)、丙二醛(MDA)、一氧化氮(NO)含量,超氧化物歧化酶(SOD)、总一氧化氮合酶(TNOS)、诱导型一氧化氮合酶(iNOS)、线粒体ATP酶(ATPase)活性和血清ALT、AST水平。结果叶黄素各剂量组小鼠肝组织MDA、ROS含量低于模型对照组;高剂量组SOD活性高于模型对照组,TNOS、iNOS活性低于模型组,肝线粒体Na+-K+-ATP酶活性高于模型组,差异均有统计学意义(P0.05)。结论叶黄素可降低D-gal致氧化应激小鼠体内ROS和NOS活性,提高SOD和线粒体Na+-K+-ATP酶活性,从而缓解氧化应激损伤。
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| 关 键 词： | 叶黄素 D-半乳糖氧化应激 线粒体 一氧化氮合成酶 |
Protective effect of lutein on oxidative mice induced by D-galatose |
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| MAI Jia-yi,SHEN Xin-nan,WEI Yan,WU Min,YAO Guo-ying.Protective effect of lutein on oxidative mice induced by D-galatose[J].China Preventive Medicine,2010(4):346-349. |
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| Authors: | MAI Jia-yi SHEN Xin-nan WEI Yan WU Min YAO Guo-ying |
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| Institution: | MAI Jia-yi,SHEN Xin-nan,WEI Yan,WU Min,YAO Guo-ying.Department of Nutrition , Food Hygiene,School of Public Health,Fudan University,Shanghai 200032,China |
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| Abstract: | Objective To study the antioxidant effect of lutein on oxidative mice induced by D-galactose(D-gal).Methods Forty-six mice of Kunming strain were randomly assigned into 4 groups including high lutein dose group(HL,lutein 40 mg/kg body weight per day for 6 weeks),low lutein dose group(LL,lutein 10 mg/kg),D-gal induced model and normal control groups.All groups of mice were tested for the concentrations of malondialdehyde(MDA),reactive oxygen species(ROS),nitric oxide(NO),superoxide dismutase(SOD),total nitri... |
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| Keywords: | Lutein Malondialdehyde Superoxide dismutase Oxidative stress Mitochondrial Nitric oxide synthase |
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