| 氨咖黄敏胶囊中马来酸氯苯那敏含量及含量均匀度测定 |
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| 引用本文： | 吴珺,吴虹萍.氨咖黄敏胶囊中马来酸氯苯那敏含量及含量均匀度测定[J].中国药业,2008,17(9):32-33. |
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| 作者姓名： | 吴珺 吴虹萍 |
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| 作者单位： | 1. 江苏省泰州市药品检验所,江苏,泰州,225300
2. 江苏省兴化市第四人民医院,江苏,兴化,225741 |
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| 摘 要： | 目的建立高效液相色谱（HPLC）法，测定氨咖黄敏胶囊中马来酸氯苯那敏含量及含量均匀度。方法采用Agilent C18柱（150mm×4．6mm，5μm），以甲醇-0．01mol／L磷酸二氢钾-0．02mol／L庚烷磺酸钠（58．5：35．5：6）为流动相，流速为1mL／min，检测波长为215an]，柱温为25℃。结果马来酸氯苯那敏质量浓度在11．99—47．98μg／mL（r=0．9998）范围内与峰面积线性关系良好，平均加样回收率为99．17％，RSD=0．2％（n=6）。结论HPLC法简便、快速，重现性良好。
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| 关 键 词： | 高效液相色谱法 氨咖黄敏胶囊 马来酸氯苯那敏 含量 含量均匀度 |
| 文章编号： | 1006-4931(2008)09-0032-02 |
| 修稿时间： | 2007年6月24日 |
Determination of Content and Uniformity of Chlorphenamine Maleate in Ankahuangmin Capsules by HPLC |
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| Wu Jun,Wu Hongping.Determination of Content and Uniformity of Chlorphenamine Maleate in Ankahuangmin Capsules by HPLC[J].China Pharmaceuticals,2008,17(9):32-33. |
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| Authors: | Wu Jun Wu Hongping |
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| Institution: | Wu Jun, Wu Hongping(1. Taizhou Institute for Drug Control of Jiangsu Province, Taizhov, Jiangsu, China 225300; 2. Forth Hospital of Xinghua City, Xinghua, Jiangsu, China 225741) |
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| Abstract: | Objective To establish the HPLC method for the content and uniformity of chlorphenamine maleate in Ankahuangmin Capsules. Methods Agilent C18 column （150 mm ×4. 6 mm, 5μm） was used. The mobile phase was methanol-0. 01 mol/L monopotassium phosphate - 0.02 mol/L 1 -heptane sulfonic acid sodium salt （58.5 ： 35.5 ： 6）. The flow rate was 1 mL/min. The detection wavelength was 215 nm and the column temperature was 25 ℃. Results The linear range of chlorphenamine maleate was 11.99-47.98 μg/mL（ r =0. 999 8）. The average recovery rate was 99.17% , RSD = 0. 2% （ n = 6）. Conclusion The method is simple, quick and precise. |
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| Keywords: | HPLC Ankahuangmin Capsules chlorphenamine maleate content content uniformity |
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