Expressions of GSK-3beta, Beta-catenin and PPAR-gamma in medulloblastoma |
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Authors: | Xiong Zhang Lu Si Yu Li Can Mi |
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Institution: | (1) Institute of Neuroscience, Chongqing Medical University, Chongqing, 400016, China;(2) Department of Pathology, Chongqing Medical University, Chongqing, 400016, China |
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Abstract: | Objective To investigate the expressions of GSK-3beta, Beta-catenin and PPAR-gamma, and their relationship in medulloblastoma, and to
explore their value in clinic application.
Methods Immunohistochemical staining with SP method was conducted to determine the expressions of GSK-3beta, Beta-catenin and PPAR-gamma
in 48 cases of medulloblastoma and 10 normal cerebellar tissues.
Results The rate of abnormal expressions of beta-catenin and PPAR-gamma in MB was higher than that in normal. Conversely, GSK-3beta
in MB was lower than that in the normal (P<0.05). Furthermore, in medulloblastoma, beta-catenin and GSK-3beta showed a negative correlation, PPAR-gamma and beta-catenin
had a positive correlation.
Conclusion Abnormal expression of beta-catenin plays a crucial role in the development of medulloblastoma. Meanwhile, PPAR-gamma and
GSK-3beta which are tightly related with beta-catenin are both involved in the genesis and development of medulloblastoma.
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Keywords: | Gsk-3beta Beta-catenin PPAR-gamma Medulloblastoma |
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