2型糖尿病患者颈动脉内膜-中层厚度与血液流变学指标的相关性分析

目的:探讨2型糖尿病患者颈动脉内膜-中层厚度(CIMT)与血液流变学指标的相关性。方法:选取88例糖尿病患者,检查CIMT后,分为血管病变组及无血管病变组,检测两组患者全血粘度、血浆粘度和红细胞压积、纤维蛋白原,对结果进行组间比较及CIMT与血流变指标的相关性分析。结果:血管病变组的CIMT、全血(低切、中切、高切)粘度、血浆粘度、红细胞压积、纤维蛋白原与无血管病变组比较差异有统计学意义(P<0.05);血管病变组CIMT与全血(中切、低切)粘度、血浆粘度、红细胞压积、纤维蛋白原呈显著正相关(P<0.01)。结论:糖尿病合并颈动脉血管病变患者常伴有血液流变学指标升高,血液流变学异常变化可能参与颈动脉血管病变的发生发展。

The Correlation Analysis between Hemorheology and Carotid Intima-media Thickness in Type 2 Diabetes Mellitus

Objective: To explore the relationship between hemorheology and carotid intima-media thickness(CIMT)in patients with type 2 diabetes(T2DM). Method: Eighty eight patients with T2DM were enrolled in this study.According to the results of CIMT,they were divided into two groups:non-macroangiopathy group and combined with macroangiopathy group,the levels of the index of hemorheology in two groups were detected and compared,and the relationship of CIMT and the index of hemorheology was also analyzed. Results: There was significant difference of CIMT, whole blood viscosity(low shear,middle shear,high shear),plasma viscosity,hematocrit and fibrinogen in two groups(P<0.05).And whole blood viscosity(middle shear,low shear),plasma viscosity,hematocrit,fibrinogen were positively relative with CIMT(P<0.01). Conclusion: The patients with T2DM combined with macroangiopathy have obvious changes of hemorheology, it means abnormal hemorheology may play a role in the formation and development of macroangiopathy.