联合吸入硫酸镁及沙丁胺醇治疗哮喘的临床研究

目的：探讨联合吸入7.5%等渗硫酸镁及1％沙丁胺醇对发作期哮喘患肺功能的影响。方法：将75例发作期哮喘患随机分成A、B、C3组，每组25人，A组雾化吸入7.5%等渗硫酸镁溶液3ml后间歇5min，再吸入生理盐水3ml。B组雾化吸入0.1%沙丁胺醇3ml后，间歇5min再吸入生理盐水3ml。C组雾化吸入0.1%沙丁胺醇3ml后，间歇5min再雾化吸入7.5%等渗硫酸镁溶液3ml。于吸药前、后15min分界和肺活量（FVC）、1秒钟用力呼气容积（FEV1）、最大呼气流量（PEF）的检测，并分别测A、C两组吸药前后收缩压、舒张压、心率、呼吸的变化。结果：3组吸药前后肺功能指标占其正常预计值的百分比浓度（FVC％、FEV1％、PEF％）比较均有显性差异（P＜0．05）；3组间吸药后15min肺功能比较：B组显高于A组（P＜0．05）；C组非常显高于B组（P＜0．01）和A组（P＜0．01）。A组及C组吸药前后收缩压、舒张率、心率和呼吸频率差异均无显性（P＞0．05）。结论：联合吸入7．5％等渗硫酸镁及1％沙丁胺醇对发作期哮喘患的治疗有协同作用，能明显改善通气功能，且对患的血压、心率、呼吸无明显影响。

Clinical study of salbutamol combined with magnesium sulfate by nebulization in the treatment of paroxysmal asthma

AIM: To explore the efficacy of salbutamol combined with magnesium sulfate by nebulization in the treatment of paroxysmal asthma. METHODS: All of 75 asthma patients were divided into three groups of A, B, and C (n=25): A group treated with 3 ml of 7.5 % isoosmotic magnesium sulfate solution and 3 ml of physiology saline 5 minutes later; B group treated with 3 ml of 0.1 % salbutamol solution and 3 ml of Physiology saline 5 minutes later; C group treated with 3 ml of 0.1 % salbutamol solution and 3 ml of 7.5 % isoosmotic magnesium sulfate solution 5 min later. Forced vital capacity (FVC), forced expiratory volume in the first second (FEV1), peak expiratory flow (PEF) in the three groups were tested before and after the treatment 15 min respectively; systolic, diastolic, heart rates and respirations were tested between group A and group C as well. RESULTS: Significant differences were found in ratios (FVC%, FEV1%, PEF%) of actual indexes of lung function (FVC, FEV1, PEF) to the predicted indexes between before and after treatment in the three groups (P< 0.05 ). The lung function of B group was higher than that of A group (P< 0.05 ) and C higher than A and B (P< 0.01 ). There was not significant difference between A and C groups in systolic, diastolic, heart rates and respirations before and after treatment (all of P< 0.05 ). CONCLUSION: There is a synergism in the nebulization inspirating of 0.1 % salbutamol combined with 7.5 % isoosmotic magnesium sulfate in the treatment of paroxysmal asthma. It can improve ventilation function, but does not affect the blood pressure, heart rates and respirations.