T lymphocyte subpopulations in the bone marrow and peripheral blood of untreated patients with myeloma |
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Authors: | Rosario Giustolisi Patrizia Guglielmo Michele Rizzo Elio Cacciola |
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Institution: | (1) Cattedra di Ematologia, Università degli Studi di Catania Ospedale Ferrarotto, Via S. Citelli, 95124 Catania, Italia |
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Abstract: | Summary The quantitative distribution of the two main T lymphocyte subsets, recognizable by the ‘high’ and ‘low-affinity’ E rosette-forming
cell technique of West, was studied in both the bone marrow and peripheral blood from ten untreated multiple myeloma (MM)
patients. A reduced total T lymphocyte count, with a relative predominance of ‘low-affinity’ T lymphocytes (putative suppressor
T cells), was found in the peripheral blood. Within a normal total T lymphoid cell count, a predominance of the T lymphocyte
subset with ‘low-affinity’ characteristics was also observed in the bone marrow. An inverse correlation, that was statistically
significant, was seen between the monoclonal malignant cellular B component and the ‘low-affinity’ T cell percentage in all
cases. It is concluded, therefore, that such an imbalance between the ‘high’ and ‘low-affinity’ T subsets, with the latter
predominating, could be of importance in the regulation of the growth rate of the monoclonal cellular B component. |
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Keywords: | Bone marrow T lymphocytes Multiple myeloma T lymphocyte subpopulations |
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