Recurrence of anti-glomerular basement membrane antibody mediated glomerulonephritis in an isograft |
| |
| Affiliation: | 1. Department Organs of Sense, ENT Section, ''Sapienza'' University of Rome, Viale del Policlinico 155, 00100 Roma, Italy;2. Department of Surgical Science, ''Sapienza'' University of Rome, Viale del Policlinico 155, 00100 Roma, Italy;3. Department of Medico-Surgical Sciences and Biotechnologies, Otorhinolaryngology Section, ''Sapienza'' University of Rome, Corso della Repubblica, 79, 04100 Latina, LT, Italy;4. Department Organs of Sense, Audiology Section, ''Sapienza'' University of Rome, Viale del Policlinico 155, 00100 Roma, Italy |
| |
| Abstract: | A renal isograft was performed without immunosuppression in a patient with Goodpasture's syndrome, whose anti-glomerular basement membrane (GBM) antibody titer by radioimmunoassay had been undetectable for more than 1 year. Within 2 weeks of the transplant hematuria and proteinuria were noted, and 5 months post-transplant renal biopsy showed linear IgG deposits in glomerular basement membrane and the anti-GBM antibody titer rose. Treatment with steroids, azathioprine, and plasmapheresis was instituted. The glomerular filtration rate has remained normal, and the anti-GBM antibody titer fell and has remained undetectable. Follow-up is now more than 3 years. The data suggest that reintroduction of renal tissue stimulated reappearance of anti-GBM antibody. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
