Xanthones and anthraquinones from the soil fungus Penicillium sp. DWS10-P-6 |
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| Authors: | Ya-jing Wang Nan Ma Chun-yue Liu Yi-xuan Feng Feng-xiang Zhang Chang Li Yue-hu Pei |
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| Affiliation: | Department of Medicinal Chemistry and Natural Medicine Chemistry, College of Pharmacy, HarBin Medical University, HarBin 150081 People''s Republic of China.; Shenyang Pharmaceutical University, Shenyang 110016 People''s Republic of China ; The First Affiliated Hospital of Jinan University, GuangZhou 510632 People''s Republic of China |
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| Abstract: | Two new xanthones, oxisterigmatocystins J and K (1–2), and two new anthraquinones, versicolorins D and E (3–4), were isolated from solid cultures of the fungus Penicillium sp. DWS10-P-6, together with twelve known compounds (5–16). Their structures, including their absolute configurations, were characterized on the basis of extensive 1D NMR, 2D NMR, MS and CD spectral data. The cytotoxic activities of compounds 1–12 against HL-60, MDA-MB-231 and PC-3 cells were also evaluated. Compounds 4 and 5 showed significant cytotoxic activity against the HL-60 cell line with IC50 values of 1.65 μM and 1.05 μM, respectively.Two new xanthones, oxisterigmatocystins J and K, and two new anthraquinones, versicolorins D and E, were characterized from the fungus Penicillium sp. Compounds 4 and 5 showed significant cytotoxic activities against HL-60 cell line. |
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